Ms. Yanjie Wang Profile

Yanjie Wang

Graduate Student at Toronto Metropolitan Univ

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Publications (9)

SPIE Journal Paper | 21 January 2022 Open Access

Effects of shell-integrated Sudan Black dye on the acoustic activity and ultrasound imaging properties of lipid-shelled nanoscale ultrasound contrast agents

Dana Wegierak, Grace Fishbein, Eric Abenojar, Al Christopher De Leon, Jinle Zhu, Yanjie Wang, Charlotte Ferworn, Agata Exner, Michael Kolios

JBO, Vol. 27, Issue 01, 016501, (January 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.1.016501

KEYWORDS: Niobium, Signal detection, Acoustics, Magnesium, Transducers, Nonlinear optics, Ultrasonography, Absorption, Transmission electron microscopy, Particles

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Significance: An effective contrast agent for concurrent multimodal photoacoustic (PA) and ultrasound (US) imaging must have both high optical absorption and high echogenicity. Integrating a highly absorbing dye into the lipid shell of gas core nanobubbles (NBs) adds PA contrast to existing US contrast agents but may impact agent ultrasonic response. Aim: We report on the development and ultrasonic characterization of lipid-shell stabilized C3F8 NBs with integrated Sudan Black (SB) B dye in the shell as dual-modal PA-US contrast agents. Approach: Perfluoropropane NBs stabilized with a lipid shell including increasing concentrations of SB B dye were formulated by amalgamation (SBNBs). Physical properties of SBNBs were characterized using resonant mass measurement, transmission electron microscopy and pendant drop tensiometry. Concentrated bubble solutions were imaged for 8 min to assess signal decay. Diluted bubble solutions were stimulated by a focused transducer to determine the response of individual NBs to long cycle (30 cycle) US. For assessment of simultaneous multimodal contrast, bulk populations of SBNBs were imaged using a PA and US imaging platform. Results: We produced high agent yield (∼1011) with a mean diameter of ∼200 to 300 nm depending on SB loading. A 40% decrease in bubble yield was measured for solutions with 0.3 and 0.4 mg / ml SB. The addition of SB to the shell did not substantially affect NB size despite an increase in surface tension by up to 8 mN / m. The bubble decay rate increased after prolonged exposure (8 min) by dyed bubbles in comparison to their undyed counterparts (2.5-fold). SB in bubble shells increased gas exchange across the shell for long cycle US. PA imaging of these agents showed an increase in power (up to 10 dB) with increasing dye. Conclusions: We added PA contrast function to NBs. The addition of SB increased gas exchange across the NB shell. This has important implications in their use as multimodal agents.

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Proceedings Article | 5 March 2021 Presentation

Photoacoustic-derived biomarkers of nanobubble-mediated cancer treatment response

Eno Hysi, Muhannad Fadhel, Yanjie Wang, Joseph Sebastian, Anoja Giles, Gregory Czarnota, Agata Exner, Michael Kolios

Proceedings Volume 11642, 116422M (2021) https://doi.org/10.1117/12.2577090

KEYWORDS: Tumors, Cancer, Oncology, Niobium, Ultrasonography, Tissue optics, Radiotherapy, Prostate cancer, Photoacoustic spectroscopy, Photoacoustic imaging

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Proceedings Article | 20 April 2020 Presentation

Fundamental studies comparing nanobubbles and microbubbles as vascular disrupting agents: Elucidating on the mechanism of action using photoacoustic imaging (Conference Presentation)

Eno Hysi, Muhannad Fadhel, Anoja Giles, Yanjie Wang, Joseph Sebastian, Gregory Czarnota, Agata Exner, Michael Kolios

Proceedings Volume 11240, 1124029 (2020) https://doi.org/10.1117/12.2544302

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Proceedings Article | 4 March 2019 Presentation

Targeted Sudan Black nanobubbles as photoacoustic contrast agents for breast cancer imaging (Conference Presentation)

Yanjie Wang, Eno Hysi, Michael Moore, Al Christopher De Leon, Eric Abenojar, Agata Exner, Michael Kolios

Proceedings Volume 10878, 108782F (2019) https://doi.org/10.1117/12.2510876

KEYWORDS: Photoacoustic spectroscopy, Tumors, Breast cancer, Mammography, Ultrasonography, In vivo imaging, Breast, Chemistry, Photoacoustic imaging, Nonlinear optics

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Proceedings Article | 27 February 2019 Presentation + Paper

Individual nanobubbles detection using acoustic based flow cytometry

Vaskar Gnyawali, Jun-Zhi Wang, Yanjie Wang, Grace Fishbein, Lianne H. So, Al Christopher De Leon, Eric Abenojar, Agata Exner, Scott Tsai, Michael Kolios

Proceedings Volume 10878, 108782E (2019) https://doi.org/10.1117/12.2510783

KEYWORDS: Signal detection, Ultrasonography, Backscatter, Photoacoustic spectroscopy, Acoustics, Microfluidics, Flow cytometry, Transducers, Imaging systems, Ultrasonics, Nano contrast agents

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Proceedings Article | 26 April 2016 Presentation

Visualization and characterization of the acoustic radiation force assisted displacement of particles using an OCT technique (Conference Presentation)

Marjan Razani, Azhar Zam, Nico J. Arezza, Yan Wang, Michael Kolios

Proceedings Volume 9707, 970708 (2016) https://doi.org/10.1117/12.2211674

KEYWORDS: Particles, Optical coherence tomography, Acoustics, Image enhancement, Nanoparticles, Collagen, Visualization, Speckle, Gold, 3D image processing

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Proceedings Article | 15 March 2016 Presentation + Paper

Biodegradable polymer based theranostic agents for photoacoustic imaging and cancer therapy

Yan Wang, Eric Strohm, Michael Kolios

Proceedings Volume 9708, 970826 (2016) https://doi.org/10.1117/12.2212999

KEYWORDS: Particles, Ultrasonography, Gold, Polymers, Nanoparticles, Photoacoustic imaging, Cancer, Liquids, Picture Archiving and Communication System, Laser ablation

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Proceedings Article | 19 March 2015 Paper

Multifunctional perfluorocarbon nanoemulsions for cancer therapy and imaging

Donald Fernandes, Dennis Fernandes, Yan Wang, Yuchong Li, Claudiu Gradinaru, Dérick Rousseau, Michael Kolios

Proceedings Volume 9338, 93380R (2015) https://doi.org/10.1117/12.2079914

KEYWORDS: Nanoparticles, Gold, Fluorescence correlation spectroscopy, Luminescence, Transmission electron microscopy, Cancer, Silica, Neon, Microscopy, Photoacoustic spectroscopy

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Proceedings Article | 3 March 2014 Paper

PLGA/PFC particles loaded with gold nanoparticles as dual contrast agents for photoacoustic and ultrasound imaging

Yan Wang, Eric Strohm, Yang Sun, Chengcheng Niu, Yuanyi Zheng, Zhigang Wang, Michael Kolios

Proceedings Volume 8943, 89433M (2014) https://doi.org/10.1117/12.2037907

KEYWORDS: Particles, Photoacoustic spectroscopy, Gold, Liquids, Silica, Ultrasonography, Nanoparticles, Laser damage threshold, Transducers, Polymers

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Showing 5 of 9 publications

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