Preclinical studies and clinical diagnostics increasingly rely on optical techniques to visualize internal organs. Miniaturised catheters or endoscopes are necessary for imaging small and/or delicate arteries. However, current lens fabrication methods limit the performance of these ultrathin devices, resulting in a poor combination of resolution, depth of focus and multimodal imaging capability. This talk will introduce our latest research to address these combined challenges. In particular, we have utilized 3D micro-printing technology to fabricate freeform optics directly onto an optical fiber to achieve freeform designs for aberration-corrected optical coherence tomography (OCT) and to enable highly-sensitive multimodal fluorescence+OCT imaging in vivo.
3D micro-printing enables the formation of complex shapes at a print resolution of tens of nanometers using two-photon lithography. Our team have explored the use of 3D micro-printing to fabricate complex optical geometries directly on the end of a fiber. In this work, we have developed a lens-in-lens design that enables in-vivo high-sensitivity fluorescence and OCT imaging through a single-fiber-based probe, with a diameter <550 microns including a protective catheter sheath. In a parallel work, we have also fabricated a side-facing OCT fiber probe (<300 microns diameter) creating an elongated Bessel beam and simultaneously correct for aberrations.
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