Prof. Zachary J. Smith Profile

Prof. Zachary J. Smith

Professor

SPIE Involvement:

Conference Program Committee | Author

Area of Expertise:

Biomedical Optics , Light Scattering , Biomedical instrumentaiton , optical spectroscopy , Microscopy

Websites:

Company Website

Proceedings Article | 23 November 2024 Poster

Label-free analysis of organelle interactions using organelle-specific phase contrast microscopy (OS-PCM)

Jingde Fang, Zachary Smith, Kaiqin Chu

Proceedings Volume 13238, 132380M (2024) https://doi.org/10.1117/12.3035382

KEYWORDS: Phase contrast, Microscopy, Microscopes, Mitochondria, Fluorescence, Proteins, Fluorescence imaging, Visualization, Temporal resolution, Photobleaching

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Proceedings Article | 21 November 2024 Poster

Rapid intracellular detection and analysis of lipid droplets' morpho-chemical composition by phase-guided Raman sampling

Hao Zhang, Zachary Smith

Proceedings Volume 13242, 132421L (2024) https://doi.org/10.1117/12.3034573

KEYWORDS: Raman spectroscopy, Chemical analysis, Chemical composition, Profiling, Coherence imaging, Optical coherence, Image resolution

Proceedings Article | 12 March 2024 Presentation + Paper

Dynamic azo-enhanced Raman imaging of cellular organelle physiology

Tingjuan Gao, Yajun Yu, Yuchen Tang, Zachary Smith

Proceedings Volume 12855, 1285504 (2024) https://doi.org/10.1117/12.2692597

KEYWORDS: Raman spectroscopy, Biological imaging, Raman scattering, Vibration, Mitochondria, Microscopy, Biomedical optics, Line scan image sensors, Imaging systems, Visualization, Resonance enhancement

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Proceedings Article | 4 March 2019 Presentation

Cost-effective screening of nutritional and genetic anemias with a portable light scattering system (Conference Presentation)

Zachary Smith, Lieshu Tong, Josef Kauer, Xi Chen, Hu Dou, Kaiqin Chu

Proceedings Volume 10869, 108690R (2019) https://doi.org/10.1117/12.2506572

KEYWORDS: Genetics, Light scattering, Iron, Machine learning, Diagnostics, Optical testing, Scatter measurement, Clinical trials

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Proceedings Article | 4 March 2019 Presentation

An automated parasite infection diagnostic system via open-source microscopy and deep learning (Conference Presentation)

Yaning Li, Rui Zheng, Yizhen Wu, Kaiqin Chu, Qianming Xu, Mingzhai Sun, Zachary Smith

Proceedings Volume 10869, 108690G (2019) https://doi.org/10.1117/12.2506571

KEYWORDS: Diagnostics, Microscopy, Image segmentation, Microscopes, Image resolution, Convolutional neural networks, Image analysis, Resistance

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SPIE Journal Paper | 22 February 2018 Open Access

Benchtop and animal validation of a portable fluorescence microscopic imaging system for potential use in cholecystectomy

Jian Ye, Guanghui Liu, Peng Liu, Shiwu Zhang, Pengfei Shao, Zachary Smith, Chenhai Liu, Ronald X. Xu

JBO, Vol. 23, Issue 02, 020504, (February 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.2.020504

KEYWORDS: Luminescence, Imaging systems, Injuries, Light sources, In vivo imaging, Tissues, Light emitting diodes, LCDs, Breast, Bladder

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Proceedings Article | 24 April 2017 Presentation

Field performance of a low-cost and fully-automated blood counting system operated by trained and untrained users (Conference Presentation)

Dengling Xie, Yanjun Xie, Peng Liu, Lieshu Tong, Kaiqin Chu, Zachary Smith

Proceedings Volume 10072, 100720H (2017) https://doi.org/10.1117/12.2250685

KEYWORDS: Blood, Luminescence, Hematology, Capillaries, Microscopes, 3D metrology, Statistical analysis, Gold, Optical diagnostics, Optical sensing

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Proceedings Article | 19 April 2017 Presentation

Evaluation of anemia diagnosis based on elastic light scattering (Conference Presentation)

Lieshu Tong, Xinrui Wang, Dengling Xie, Xiaoya Chen, Kaiqin Chu, Hu Dou, Zachary Smith

Proceedings Volume 10055, 100550E (2017) https://doi.org/10.1117/12.2250686

KEYWORDS: Current controlled current source, Iron, Light scattering, Scattering, Diagnostics, Blood, Particles, Data processing, Measurement devices, Biomedical optics

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Proceedings Article | 3 April 2017 Paper

Time-resolved SERS for characterizing extracellular vesicles

Tatu Rojalin, Heikki Saari, Petter Somersalo, Saara Laitinen, Mikko Turunen, Tapani Viitala, Sebastian Wachsmann-Hogiu, Zachary Smith, Marjo Yliperttula

Proceedings Volume 10080, 100800U (2017) https://doi.org/10.1117/12.2271865

KEYWORDS: Surface enhanced Raman spectroscopy, Raman spectroscopy, Data analysis, Blood, Polymers, Spectroscopy, Principal component analysis, Pharmacy, Precision mechanics, Nanoparticles

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Proceedings Article | 31 October 2016 Paper

Structured light imaging system for structural and optical characterization of 3D tissue-simulating phantoms

Songde Liu, Zach Smith, Ronald Xu

Proceedings Volume 10024, 100240P (2016) https://doi.org/10.1117/12.2247773

KEYWORDS: Imaging systems, Optical properties, Tissue optics, Structured light, Absorption, Scattering, Calibration, System integration, Integrating spheres, Cameras

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Proceedings Article | 3 May 2016 Presentation

Raman spectroscopy of single extracellular vesicles reveals subpopulations with varying membrane content (Conference Presentation)

Zachary Smith, Changwon Lee, Tatu Rojalin, Randy Carney, Sidhartha Hazari, Alisha Knudson, Kit Lam, Heikki Saari, Elisa Lazaro Ibañez, Tapani Viitala, Timo Laaksonen, Marjo Yliperttula, Sebastian Wachsmann-Hogiu

Proceedings Volume 9704, 97040Q (2016) https://doi.org/10.1117/12.2212914

KEYWORDS: Raman spectroscopy, Proteins, Cancer, Chemical analysis, Biomedical optics, Laser spectroscopy, Principal component analysis, Industrial chemicals, Spectroscopy, Medical research

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Proceedings Article | 27 April 2016 Presentation

Smart fast blood counting of trace volumes of body fluids from various mammalian species using a compact custom-built microscope cytometer (Conference Presentation)

Zachary Smith, Tingjuan Gao, Tzu-Yin Lin, Danielle Carrade-Holt, Stephen Lane, Dennis Matthews, Denis Dwyre, Sebastian Wachsmann-Hogiu

Proceedings Volume 9715, 97150J (2016) https://doi.org/10.1117/12.2212881

KEYWORDS: Blood, Microfluidics, Microscopes, Biomedical optics, Diagnostics, Flow cytometry, Statistical analysis, Optical diagnostics, Optical sensing, Point-of-care devices

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Proceedings Article | 7 March 2016 Presentation + Paper

In vivo detection of cervical intraepithelial neoplasia by multimodal colposcopy

Wenqi Ren, Yingjie Qu, Jiaojiao Pei, Linlin Xiao, Shiwu Zhang, Shufang Chang, Zachary Smith, Ronald Xu

Proceedings Volume 9701, 97010E (2016) https://doi.org/10.1117/12.2212194

KEYWORDS: Image segmentation, In vivo imaging, Multispectral imaging, Cervical cancer, Reflectivity, RGB color model, Monte Carlo methods, Tissues, Multimodal imaging, Image enhancement, Image processing, Algorithm development

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SPIE Journal Paper | 1 May 2010 Open Access

Integrated Raman and angular scattering microscopy reveals chemical and morphological differences between activated and nonactivated CD8+ T lymphocytes

Zachary Smith, Jyh-Chiang Wang, Sally Quataert, Andrew Berger

JBO, Vol. 15, Issue 03, 036021, (May 2010) https://doi.org/10.1117/12.10.1117/1.3443794

KEYWORDS: Raman spectroscopy, Scattering, Raman scattering, Microscopy, Proteins, Flow cytometry, Microscopes, Scatter measurement, Laser scattering, Light scattering

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Proceedings Article | 10 March 2008 Paper

Integrated Raman and angular scattering microscopy (IRAM)

Zachary Smith, Andrew Berger

Proceedings Volume 6853, 68530T (2008) https://doi.org/10.1117/12.761796

KEYWORDS: Raman scattering, Scattering, Raman spectroscopy, Laser scattering, Light scattering, Optical spheres, Microscopes, Mie scattering, Beam shaping, Microscopy

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Showing 5 of 15 publications

Conference Committee Involvement (6)

Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXXII

29 January 2025 | San Francisco, California, United States

Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXXI

31 January 2024 | San Francisco, California, United States

Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXX

1 February 2023 | San Francisco, California, United States

Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXIX

26 January 2022 | San Francisco, California, United States

Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVIII

6 March 2021 | Online Only, California, United States

Showing 5 of 6 Conference Committees

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