Polymer dots with broadband optical absorption (500 nm - 700 nm) and high-efficiency photoacoustic conversion for in vivo multispectral photoacoustic imaging

Jian Zhang; Zhen Yuan

doi:10.1117/12.2245654

31 October 2016 Polymer dots with broadband optical absorption (500 nm - 700 nm) and high-efficiency photoacoustic conversion for in vivo multispectral photoacoustic imaging

Jian Zhang, Zhen Yuan

Author Affiliations +

Proceedings Volume 10024, Optics in Health Care and Biomedical Optics VII; 100242A (2016) https://doi.org/10.1117/12.2245654
Event: SPIE/COS Photonics Asia, 2016, Beijing, China

Abstract

Multi-spectral photoacoustic (MSPA) imaging can extract quantitative information of interesting component from morphological photoacoustic image of targets. A probe with an optimal optical absorption can be detected by MSPA imaging with higher sensitivity and specificity. Here we developed a Nano polymers dots (P-dots) for MSPA imaging that has a high photoacoustic conversion efficiency in a broad optical absorbing band (500 nm - 700 nm). In vivo MSPA imaging experiment was successfully performed in mouse model. The relative concentration map of P-dots was exactly obtained from the background of tissues, which demonstrated the potential use of P-dots in the bio-imaging field based on MSPA imaging.

Citation Download Citation

Jian Zhang and Zhen Yuan "Polymer dots with broadband optical absorption (500 nm - 700 nm) and high-efficiency photoacoustic conversion for in vivo multispectral photoacoustic imaging", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100242A (31 October 2016); https://doi.org/10.1117/12.2245654

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available