Lymphatic imaging in unsedated infants and children

John C. Rasmussen; Duraisamy Balaguru; William I. Douglas; John P. Breinholt; Matthew R. Greives; Melissa B. Aldrich; Eva M. Sevick-Muraca

doi:10.1117/12.2256753

14 February 2017 Lymphatic imaging in unsedated infants and children

John C. Rasmussen, Duraisamy Balaguru, William I. Douglas, John P. Breinholt, Matthew R. Greives, Melissa B. Aldrich, Eva M. Sevick-Muraca

Author Affiliations +

Proceedings Volume 10054, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV; 100540U (2017) https://doi.org/10.1117/12.2256753
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Primary lymphedema and lymphatic malformations in the pediatric population remains poorly diagnosed and misunderstood due to a lack of information on the underlying anatomy and function of the lymphatic system. Diagnostics for the lymphatic vasculature are limited, consisting of lymphoscintigraphy or invasive lymphangiography, both of which require sedation that can restrict use in infants and children. As a result, therapeutic protocols for pediatric patients with lymphatic disorders remain sparse and with little evidence to support them. Because near-infrared fluorescence (NIRF) imaging enables image acquisition on the order of tenths of seconds with trace administration of fluorescent dye, sedation is not necessary. The lack of harmful radiation and radioactive contrast agents further facilitates imaging. Herein we summarize our experiences in imaging infants and children who are suspected to have disorders of the lymphatic vascular system using indocyanine green (ICG) and who have developed chylothorax following surgery for congenital heart defects. The results show both anatomical as well as functional lymphatic deficits in children with congenital disease. In the future, NIRF lymphatic imaging could provide new opportunities to tailor effective therapies and monitor responses. The opportunity to use expand NIRF imaging for pediatric diagnostics beyond the lymphatic vasculature is also afforded by the rapid acquisition following trace administration of NIRF contrast agent.

Conference Presentation

Citation Download Citation

John C. Rasmussen, Duraisamy Balaguru, William I. Douglas, John P. Breinholt, Matthew R. Greives, Melissa B. Aldrich, and Eva M. Sevick-Muraca "Lymphatic imaging in unsedated infants and children", Proc. SPIE 10054, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV, 100540U (14 February 2017); https://doi.org/10.1117/12.2256753

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available