Second generation sensitizers: where are we and where should we be going?

Alan R. Morgan

doi:10.1117/12.2283669

21 January 1990 Second generation sensitizers: where are we and where should we be going?

Alan R. Morgan

Proceedings Volume 10306, Future Directions and Applications in Photodynamic Therapy; 1030607 (1990) https://doi.org/10.1117/12.2283669
Event: SPIE Institutes for Advanced Optical Technologies 6, 1990, San Diego, California, United States

Abstract

In recent years, a number of new photosensitizers have been proposed as alternatives to Photofrin II, for use in photodynamic therapy. Most studies in this area have targeted the absorption characteristics of the photosensitizer as the important parameter however there is currently no general consensus on where this absorption should be. In this article, the spectroscopic requirements for photodynamic therapy are examined with respect to generation of phototoxic species, penetration of light through tissues, tumor location and compatibility with available light sources. Finally, additional properties which may dictate the choice of sensitizer, such as stability, purity, hydrophobicity and biological lifetime are discussed.

Citation Download Citation

Alan R. Morgan "Second generation sensitizers: where are we and where should we be going?", Proc. SPIE 10306, Future Directions and Applications in Photodynamic Therapy, 1030607 (21 January 1990); https://doi.org/10.1117/12.2283669

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