Psoralen photobiology and photochemotherapy: perspectives and prospects

Francis P. Gasparro

doi:10.1117/12.2283677

21 January 1990 Psoralen photobiology and photochemotherapy: perspectives and prospects

Francis P. Gasparro

Proceedings Volume 10306, Future Directions and Applications in Photodynamic Therapy; 103060F (1990) https://doi.org/10.1117/12.2283677
Event: SPIE Institutes for Advanced Optical Technologies 6, 1990, San Diego, California, United States

Abstract

For nearly 40 years the field of psoralen photobiology has been focused on the effects of photoactivated 8-MOP on nuclear DNA. The results of these extensive studies are reviewed. In addition, new targets for modification are described. 8-MOP and UVA was first used to treat skin afflicted with two common dermatological disorders, vitiligo and psoriasis. More recently, several other disease have been treated using an extracorporeal form of this photochemotherapy in which the patient's blood is irradiated with UVA. Clinical results and possible modes of action are described.

Citation Download Citation

Francis P. Gasparro "Psoralen photobiology and photochemotherapy: perspectives and prospects", Proc. SPIE 10306, Future Directions and Applications in Photodynamic Therapy, 103060F (21 January 1990); https://doi.org/10.1117/12.2283677

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