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The papers in this volume were part of the technical conference cited on the cover and title page. Papers were selected and subject to review by the editors and conference program committee. Some conference presentations may not be available for publication. Additional papers and presentation recordings may be available online in the SPIE Digital Library at SPIEDigitalLibrary.org. The papers reflect the work and thoughts of the authors and are published herein as submitted. The publisher is not responsible for the validity of the information or for any outcomes resulting from reliance thereon. Please use the following format to cite material from these proceedings: Author(s), “Title of Paper,” in Light-Based Diagnosis and Treatment of Infectious Diseases, edited by Tianhong Dai, Proceedings of SPIE Vol. 10479 (SPIE, Bellingham, WA, 2018) Seven-digit Article CID Number. ISSN: 1605-7422 ISSN: 1996-756X (electronic) ISBN: 9781510614437 ISBN: 9781510614444 (electronic) Published by SPIE P.O. Box 10, Bellingham, Washington 98227-0010 USA Telephone +1 360 676 3290 (Pacific Time)· Fax +1 360 647 1445 Copyright © 2018, Society of Photo-Optical Instrumentation Engineers. Copying of material in this book for internal or personal use, or for the internal or personal use of specific clients, beyond the fair use provisions granted by the U.S. Copyright Law is authorized by SPIE subject to payment of copying fees. The Transactional Reporting Service base fee for this volume is $18.00 per article (or portion thereof), which should be paid directly to the Copyright Clearance Center (CCC), 222 Rosewood Drive, Danvers, MA 01923. Payment may also be made electronically through CCC Online at copyright.com. Other copying for republication, resale, advertising or promotion, or any form of systematic or multiple reproduction of any material in this book is prohibited except with permission in writing from the publisher. The CCC fee code is 1605-7422/18/$18.00. Printed in the United States of America. Publication of record for individual papers is online in the SPIE Digital Library.
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AuthorsNumbers in the index correspond to the last two digits of the seven-digit citation identifier (CID) article numbering system used in Proceedings of SPIE. The first five digits reflect the volume number. Base 36 numbering is employed for the last two digits and indicates the order of articles within the volume. Numbers start with 00, 01, 02, 03, 04, 05, 06, 07, 08, 09, 0A, 0B…0Z, followed by 10-1Z, 20-2Z, etc. Anderson, John G., 1G Andreani, Dora Inés Kozusny, 1L Assis, Lívia, 1K Baptista, Alessandra, 17, 1L Barbieri, Paola, 0K Bassi, Rosane, 17 Belafdil, C., 09 Blenn, Christian, 1C Bolognese, Fabrizio, 0K Borel, Nicole, 1C Brenner, David J., 1D Buonanno, Manuela, 1D Cabrera, José Luis, 0S Carrinho Aureliano, Patrícia Michelassi, 1L Chang, Kwang Poo, 12 Cheng, Ji-Xin, 0R Cirillo, Jeffrey D., 0M Corso, Raffaele, 12 Cowan, Troy E., 1A Dai, Tianhong, 0J, 0N, 0O Decq, D., 09 Dimmer, Jesica, 0S Dong, Pu-Ting, 0R Dougall, Laura R., 1G ElHussien, Ahmed, 11 Elliott, Robert, 12 Fabian, M. Patricia, 1B Fan, Chia-Kwung, 12 Fang, Yanyan, 0N Ferrer-Espada, Raquel, 0N Fu, Guo-Liang, 12 Gal, O., 09 Galbadage, Thushara, 0M Genuer, V., 09 Ghaffari, Sahand, 14 Glowczwski, Alan, 0M Gonçalves, Silma Rodrigues, 1K Greenberg, Mitchell, 0M Gu, Ying, 0O, 0Z Gülsoy, Murat, 14 Haimov, Yuri, 07 Halachmi, Sarel, 07 Hamblin, Michael R., 11, 18 Hessling, M., 0L Hoenes, K., 0L Holtzman, Liran, 07 Huang, Liyi, 18 Huang, Ying-Ying, 11 Hui, Jie, 0R Iseri Giraldeli, Shizumi, 1L Jiang, X. P., 12 Kabas Sarp, Ayşe Sena, 14 Kashi, Yechezkel, 07 Kemal Ruhi, Mustafa, 14 Kolli, Bala K., 12 Kuratli, Jasmin, 1C Leonard, Heidi, 07 Li, Junjie, 0R Li, Ting, 0D Li, Xianglin, 0D Li, Zebin, 0D Liang, Lijia, 0R Lovelady, April, 0M MacGregor, Scott J., 1G Maclean, Michelle, 1G Maitland, Kristen C., 0M Manna, Laura, 12 Marcoux, P., 09 Marti, Hanna, 1C Martignago, Cintia, 1K Martinello, Richard A., 1B Maurin, Max, 09 Miller, Shelly L., 1B Mohammad, Haroon, 0R Morales, S., 09 Morete, Vislaine de Aguiar, 1L Myakawa, Walter, 17 Nativ, Ofer, 07 Navarro, Ricardo Scarparo, 17, 1L Ng, Dennis K. P., 12 Núñez Montoya, Susana C., 0S Nunez, Silvia Cristina, 17 Orlandi, Viviana Teresa, 0K Peccia, Jordan, 1B Pesch, Theresa, 1C Ramos Silva, Camila, 0S Randers-Pehrson, Gerhard, 1D Renno, Ana Claudia Muniz, 1K Ribeiro, Martha Simões, 0S, 17 Sarna, Tadeusz, 11 Schmid, J., 0L Schultz, E., 09 Segal, Ester, 07 Seleem, Mohamed N., 0R Sharan, Riti, 0M Shiao, Shin-Hong, 12 Shih, Neng-Yao, 12 Shuryak, Igor, 1D Smith, Robert, 0M Spellerberg, B., 0L Spotnitz, Henry M., 1D Sule, Preeti, 0M Sun, Zhiyuan, 0Z, 0Z Szewczyk, Grzegorz, 11 Tim, Carla, 1K Timoshkin, Igor V., 1G Villaverde, Antonio Balbin, 1L Wang, Xiaoyu, 0R Wang, Ying, 0J, 0O Weizman, Daniel, 07 Welch, David, 1D Wen, Xiang, 11 Wild, K., 0L Wong, Clarence T. T., 12 Zhang, Xiaoshen, 11 Zhao, Yuxia, 0Z Zhou, Shaona, 0Z Conference CommitteeSymposium Chairs
Program Track Chair Conference Chair
Conference Program Committee
Session Chairs
IntroductionInfectious diseases continue to rank high among global mortality factors and inflammations have been identified as a root case of many chronic disorders. Over 95% of the mortality caused by infections and inflammatory diseases is due to the lack of proper diagnosis and treatment. The inability of physicians to characterize infections at the point of care has led to broad overuse of broadspectrum antibiotics due to the risk of missed diagnosis. Furthermore, the rise of antibiotic-resistant pathogens has complicated the choice of the treatment. It is now indisputable that antibiotic resistance is life-threatening in the same sense as cancer, both in the number of cases and the likely outcome. In 2015, the White House announced the “National Action Plan for Combating Antibiotic-Resistant Bacteria”. It is noted in the National Action Plan that “New therapeutics, vaccines, and diagnostics are urgently needed to combat emerging and reemerging antibiotic-resistant pathogens”. Rapid, optically based diagnosis could play an important role by informing treatment during this critical initial window. In addition, light-based antimicrobial therapies have attracted increasing attention due to their ability to eradicate pathogens regardless of antibiotic resistance and the fundamental improbability of the pathogens themselves to develop resistance to these light-based therapies due to the rather non-specific nature of the targets. To communicate and disseminate new findings in the area of light-based diagnosis and treatment of infections and inflammatory diseases, to increase collaborations between research groups, and to supplement and enhance the training of early-stage researchers, we founded a new conference of “Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases (Conference 10479)” at the SPIE Photonics West BioS in 2018. Technical and scientific papers related to advanced light-based diagnostic and therapeutic technologies that push beyond the scope of the state-of-the-art in basic science and clinical practice are solicited by this conference. The topics covered in the conference include photonic diagnosis of infections using Raman spectroscopy, intrinsic phase-shift Spectroscopy, interferometric imaging, elastic light scattering, labelfree multiphoton imaging, reflectance spectrometry, confocal fluorescence imaging, etc.; and phototherapy for infections using antimicrobial photodynamic therapy, antimicrobial blue light therapy, ultraviolet C irradiation, water filtered infrared A irradiation, photodynamic vaccination, etc. The present volume contains selected papers of the new conference at the SPIE Photonics West BioS 2018, held on January 29-31, 2018 in San Francisco, California. This conference received 61 papers. After an initial review, 49 papers were selected as oral presentations and 8 as poster presentations. Each paper received 2-6 reviews. Paper 10479-26 entitled “Drug-free annihilation of methicillin-resistant staphylococcus aureus via staphyloxanthin photobleaching” and authored by Ms. Puting Dong and her colleagues from the Boston University was selected from over 300 papers from different conferences for the Translational Research Best Paper Award of SPIE Photonics West 2018. Finally, 23 papers were included for publication in the Conference Proceedings. As Conference Chair, I have many people to thank. First, I would like to extend my special thanks to Drs. Rox Anderson and Tayyaba Hasan from the Wellman Center of Photomedicine for their endorsements on my proposal. I thank all the authors who submitted their papers to the conference. I thank Conference Committee Members Dr. Kristen C. Maitland, Dr. Alessandro M. Deana, Dr. Akilan Palanisami, and Dr. Ying Wang for their valuable time devoted to reviewing the papers. I also thank all Session Chairs. The largest burden fell upon their experienced shoulders. This conference would not have had such a good start without their contributions. It is my pleasant duty to acknowledge the finical support from Ondine Biomedical Inc., Ushio Inc., and Gel4Med, Inc. Finally, I would like to give my gratitude to the SPIE staff for the conference and for assembling the Proceedings. We are looking forward to SPIE Photonics West 2019 that will be held at the same time and location next year. Tianhong Dai |
