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23 February 2018 Magnetic wire as stress controlled micro-rheometer for cytoplasm viscosity measurements
Jean-François Berret
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Proceedings Volume 10507, Colloidal Nanoparticles for Biomedical Applications XIII; 105070I (2018) https://doi.org/10.1117/12.2289015
Event: SPIE BiOS, 2018, San Francisco, California, United States
Abstract
We review here different methods to measure the bulk viscosity of complex fluids using micron-sized magnetic wires. The wires are characterized by length of a few microns and diameter of a few hundreds of nanometers. We first draw analogies between cone-and-plate rheometry and wire-based microrheology. In particular we highlight that magnetic wires can be operated as stress-controlled rheometers for two types of testing, the creep-recovery and steady shear experiments. In the context of biophysical applications, the cytoplasm of different cell lines including fibroblasts, epithelial and tumor cells is studied. It reveals that the interior of living cells can be described as a viscoelastic liquid with a static viscosity comprised between 10 and 100 Pas. We extend the previous approaches and show that the proposed technique can also provide time resolved viscosity data, which for cells display strong temporal fluctuations. The present work demonstrates the high potential of the magnetic wires for quantitative rheometry in confined espaces.
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Jean-François Berret "Magnetic wire as stress controlled micro-rheometer for cytoplasm viscosity measurements", Proc. SPIE 10507, Colloidal Nanoparticles for Biomedical Applications XIII, 105070I (23 February 2018); https://doi.org/10.1117/12.2289015
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KEYWORDS
Magnetism
Microfluidics
Data modeling
Liquids
Diffusion
Spectroscopy
Nanoparticles
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