Nowadays, different types of nano-materials are extensively used as parts or drug carriers that potentially can be developed by red blood cells (RBC). In fact there is a lack of studies of influence of nano-materials of different composition on the RBC and their interaction, especially in regards to hazards to human health. Utilizing conventional use of microscopy, optical tweezers, and scanning electron microscopy (SEM) the interaction of RBC incubated with nano-materials were examined. The results of direct observation of localization of nano-materials on the membranes of RBC show that some nano-materials influence strongly both the cells and mutual RBC interaction, resulting formation of larger cell aggregates.
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