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Using flow cytometry with a genetically encoded fluorescent sensor, vital dye and two types of apoptosis markers: PE Annexin V and TMRE, the participation of hydrogen peroxide (H2O2) in cisplatin-induced apoptosis was demonstrated. It was shown that cisplatin causes the increase of H2O2 level in early apoptotic cancer cells. Accumulation of H2O2 begins before the externalization of phosphatidylserine but after the loss of mitochondrial membrane potential. Scavenging of H2O2 prevents the cisplatin-induced apoptosis.
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Anastasiya S. Nerush, Kseniya M. Shсhukina, Irina V. Balalaeva, Anna G. Orlova, "Hydrogen peroxide level in tumor cells during cisplatin-induced apoptosis," Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 110791M (22 July 2019); https://doi.org/10.1117/12.2527195