Low-cost photoacoustic computed tomography system using light-emitting-diodes

Sumit Agrawal; Xinyi Yang; Hussain Albahrani; Christopher Fadden; Ajay Dangi; Mithun Kuniyil Ajith Singh; Sri-Rajasekhar Kothapalli

doi:10.1117/12.2546993

17 February 2020 Low-cost photoacoustic computed tomography system using light-emitting-diodes

Sumit Agrawal, Xinyi Yang, Hussain Albahrani, Christopher Fadden, Ajay Dangi, Mithun Kuniyil Ajith Singh, Sri-Rajasekhar Kothapalli

Author Affiliations +

Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 1124058 (2020) https://doi.org/10.1117/12.2546993
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Photoacoustic computed tomography (PACT) has been widely explored for studying human diseases as well as response to therapies. Most PACT systems employ a large footprint, bulky, and high-cost lasers. Light emitting diodes (LEDs) based B-mode photoacoustic imaging systems have emerged as a low cost and compact alternative, offering a unique opportunity to expedite the widespread adoption of photoacoustic imaging in clinical and resource-poor settings. The high pulse repetition rate of LEDs facilitates signal-to-noise ratio improvements through averaging in spite of lower pulse energy. Here, we present the development of first low-cost LED-based PACT system that uses multiple LED arrays and a linear ultrasound transducer to generate three-dimensional structural, functional and molecular images of the object. Similar to OPO based lasers, our LED-PACT system allows for the multi-wavelength photoacoustic imaging vital for mapping functional and molecular information. Our experiments demonstrate that this study will enable clinical and pre-clinical applications such as imaging human arthritis and whole body mouse imaging.

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Sumit Agrawal, Xinyi Yang, Hussain Albahrani, Christopher Fadden, Ajay Dangi, Mithun Kuniyil Ajith Singh, and Sri-Rajasekhar Kothapalli "Low-cost photoacoustic computed tomography system using light-emitting-diodes", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 1124058 (17 February 2020); https://doi.org/10.1117/12.2546993

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