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17 March 2020 Molecularly targeted Lipo-JICG for in vivo quantitative photoacoustic imaging (Conference Presentation)
Cayla Wood, Chang Soo Kim, Sangheon Han, Yunfei Wen, Caterina Kaffes, Jason Cook, Anil Sood, Konstantin Sokolov, Richard Bouchard
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Proceedings Volume 11319, Medical Imaging 2020: Ultrasonic Imaging and Tomography; 1131902 (2020) https://doi.org/10.1117/12.2549594
Event: SPIE Medical Imaging, 2020, Houston, Texas, United States
Abstract
Photoacoustic imaging (PAI) is a non-ionizing modality that provides high spatiotemporal resolution and resolves optical absorbers at depth, allowing for potential simultaneous therapy monitoring with quantitative molecular imaging. Liposome-encapsulated J-aggregates of indocyanine green (Lipo-JICG) are a PAI agent that can be antibody-targeted and provide high-contrast imaging. Mice with ovarian tumors were injected with either targeted or untargeted Lipo-JICGs and imaged on the MSOT inVision PAI system before injection and immediately, 30-min, and 1-hour post-injection. Lipo-JICG contrast in the tumor was statistically significantly higher in the targeted mice, indicating success in molecular targeting and unmixing accuracy of Lipo-JICGs in vivo.
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Cayla Wood, Chang Soo Kim, Sangheon Han, Yunfei Wen, Caterina Kaffes, Jason Cook, Anil Sood, Konstantin Sokolov, and Richard Bouchard "Molecularly targeted Lipo-JICG for in vivo quantitative photoacoustic imaging (Conference Presentation)", Proc. SPIE 11319, Medical Imaging 2020: Ultrasonic Imaging and Tomography, 1131902 (17 March 2020); https://doi.org/10.1117/12.2549594
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KEYWORDS
In vivo imaging
Blood
Photoacoustic imaging
Tumors
Cancer
Image resolution
Indocyanine green
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