Study on a plasmonic tilted fiber Bragg grating sensor for biomolecule AdoHcy detection

Xiaoyong Chen; Yinggang Nan; Tuan Guo

doi:10.1117/12.2564629

17 April 2020 Study on a plasmonic tilted fiber Bragg grating sensor for biomolecule AdoHcy detection

Xiaoyong Chen, Yinggang Nan, Tuan Guo

Proceedings Volume 11455, Sixth Symposium on Novel Optoelectronic Detection Technology and Applications; 114553D (2020) https://doi.org/10.1117/12.2564629
Event: Sixth Symposium on Novel Photoelectronic Detection Technology and Application, 2019, Beijing, China

Abstract

We have proposed and experimentally demonstrated a plasmonic tilted fiber Bragg grating (TFBG) biosensor for labelfree detection of small biomolecule S-adenosyl-L-homocysteine (AdoHcy) in different concentrations. The biosensor is designed as a reflective probe type with a 50-nm-thick gold film coating over the fiber surface of an 18° TFBG, together with a surface functionalization with protein lysine methyltransferase Set7 working as bio-detector. The sensor is fabricated without any destruction of fiber structural integrity, thereby ensuring the stability and reproducibility. The experimental results demonstrated that our biosensor can detect biomolecule AdoHcy with concentration as low as 1 nM. We have also measured AdoHcy in different concentrations, including 0.01, 0.1 and 10 nM, and the results indicated that as the AdoHcy concentration increases, the association ratio between AdoHcy and Set7 arises correspondingly, agreeing with the theory.

Citation Download Citation

Xiaoyong Chen, Yinggang Nan, and Tuan Guo "Study on a plasmonic tilted fiber Bragg grating sensor for biomolecule AdoHcy detection", Proc. SPIE 11455, Sixth Symposium on Novel Optoelectronic Detection Technology and Applications, 114553D (17 April 2020); https://doi.org/10.1117/12.2564629

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