Development of a Non-contact cell elastography imaging system based on quantitative phase imaging and acoustic radiation force impulse techniques for determining invasion potential of cancer cells

Sangyeon Youn; Jae Youn Hwang

doi:10.1117/12.2579026

5 March 2021 Development of a Non-contact cell elastography imaging system based on quantitative phase imaging and acoustic radiation force impulse techniques for determining invasion potential of cancer cells

Sangyeon Youn, Jae Youn Hwang

Author Affiliations +

Proceedings Volume 11647, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX; 1164714 (2021) https://doi.org/10.1117/12.2579026
Event: SPIE BiOS, 2021, Online Only

Abstract

To measure the metastatic or mechanical properties of cancer cells, various methods have been implemented. However, these methods have some shortcomings that they are time-consuming, require direct contact with cells, and are measuring accuracy is sensitive to boundary conditions of the sample. To overcome these shortcomings, in this study, we developed a cell mechanical property measurement system based on the quantitative phase imaging system and ultrasound stimulation system capable of the precise determination of the invasion potential of cancer cells. By using a developed system, it is possible to successfully measure the change in thickness due to the ultrasound stimulation of various types of cancer cells according to various acoustic pressure. In addition, the time to recover the original thickness after ultrasound stimulation was also measured with a high-speed camera to characterize the mechanical properties of the cancer cells.

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Citation Download Citation

Sangyeon Youn and Jae Youn Hwang "Development of a Non-contact cell elastography imaging system based on quantitative phase imaging and acoustic radiation force impulse techniques for determining invasion potential of cancer cells", Proc. SPIE 11647, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX, 1164714 (5 March 2021); https://doi.org/10.1117/12.2579026

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