Paper
31 December 2020 An optoelectronic biomedical method for amphetamine detection by enzyme multiplied immunoassay technique
Author Affiliations +
Proceedings Volume 11718, Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies X; 1171827 (2020) https://doi.org/10.1117/12.2571711
Event: Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies 2020, 2020, Online Only
Abstract
Amphetamines are a class of substances with a stimulating effect on the central nervous system. These were first synthesided in 1887 by Lazãr Edeleanu, a romanian chemist, in Germany, originally named phenylisopropylamine, but the stimulant effect of these was unknown until 1927, than it was resynthesized by Gordon Allens, who reported the sympathomimetic properties of amphetamines [1]. Urine amphetamine measurements were performed on the Viva-ProE analyzer (SIEMENS, Germany). The light source is a 12V-20W iodine quartz lamp. The range of scannable wavelengths with its own selection of 8 filters is as follows (340, 415, 505, 546, 570, 600, 660, 700 nm). The bandwidth is 8 - 12 nm. Photometric domain - Absorbance - 0.1 to 3.0. The authors present the results obtained by analyzing the urine samples from patients admitted in ICU II Toxicology with abuse substances overdose and working parameters of the Viva Pro-E System. Some of the results are presented. This analysis uses a threshold level of 300 ng / mL to distinguish positive and negative samples. The analysis provides only a preliminary analytical test result. A sample giving a change in the absorbance value (ΔA) equal to or even higher than the ΔA value of the Level 1 calibrator is interpreted as positive and the sample contains amphetamines or similar structural compounds or both.
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Genica Caragea, Mărgărita Forje, Ruxandra Avram, Andreea Camelia Vărzaru, Marian Vlădescu, Mihail Silviu Tudosie, and Paul Şchiopu "An optoelectronic biomedical method for amphetamine detection by enzyme multiplied immunoassay technique", Proc. SPIE 11718, Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies X, 1171827 (31 December 2020); https://doi.org/10.1117/12.2571711
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KEYWORDS
Calibration

Absorbance

Biomedical optics

Optoelectronics

Statistical analysis

Signal detection

Silver

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