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1 August 2021 Photonic liquid crystals on a single substrate for label-free protein assays
Mon-Juan Lee, Chao-Ping Pai, Po-Chang Wu, Wei Lee
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Proceedings Volume 11807, Liquid Crystals XXV; 1180707 (2021) https://doi.org/10.1117/12.2593821
Event: SPIE Organic Photonics + Electronics, 2021, San Diego, California, United States
Abstract
Label-free qualitative and quantitative protein assays were established with a single-substrate biosensing platform based on cholesteric liquid crystal (CLC) films with different ratios of the thickness d to the helical pitch P. By adjusting the amount of chiral dopant incorporated in CLC, the d/P ratio or the center wavelength of Bragg’s reflection band can be fine-tuned to achieve signal amplification or to improve detection sensitivity. The single-substrate platform eliminates the need for LC cell assembly, which requires a pair of glass substrates, and can be conveniently integrated with the format of most clinical assays performed on a single solid surface.
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Mon-Juan Lee, Chao-Ping Pai, Po-Chang Wu, and Wei Lee "Photonic liquid crystals on a single substrate for label-free protein assays", Proc. SPIE 11807, Liquid Crystals XXV, 1180707 (1 August 2021); https://doi.org/10.1117/12.2593821
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KEYWORDS
Liquid crystals
Proteins
Photonic crystals
Photonic liquid crystal fibers
Biosensing
LCDs
Optical properties
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