Detection of surgical margins in head and neck cancer with dynamic optical contrast imaging

Kenric Tam; Shan Huang; Yazeed Alhiyari; Jeffrey Krane; Oscar Stafsudd; Ramesh Shori; Maie St. John

doi:10.1117/12.2608865

9 March 2022 Detection of surgical margins in head and neck cancer with dynamic optical contrast imaging

Kenric Tam, Shan Huang, Yazeed Alhiyari, Jeffrey Krane, Oscar Stafsudd, Ramesh Shori, Maie St. John

Proceedings Volume 11935, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2022; 1193506 (2022) https://doi.org/10.1117/12.2608865
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Due to the anatomic confines of the head and neck, resection of oropharyngeal squamous cell carcinoma (OPSCC) necessitates precise margins that balance oncologic outcomes with preservation of speech and swallowing. Dynamic Optical Contrast Imaging (DOCI) is a novel non-invasive imaging system that measures endogenous fluorescence decay rates. DOCI acquires images in real-time (<2 secs) with an operatively relevant wide field of view (6.5 cm²). After surgical excision, 10 OPSCC specimens were imaged using DOCI. In all 10 specimens, DOCI clearly differentiated healthy tissue from cancer (p<0.01). DOCI has the potential to improve patient oncologic and functional outcomes by allowing the surgeon to precisely determine margins intraoperatively.

Conference Presentation

Citation Download Citation

Kenric Tam, Shan Huang, Yazeed Alhiyari, Jeffrey Krane, Oscar Stafsudd, Ramesh Shori, and Maie St. John "Detection of surgical margins in head and neck cancer with dynamic optical contrast imaging", Proc. SPIE 11935, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2022, 1193506 (9 March 2022); https://doi.org/10.1117/12.2608865

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