Gliotransmitter-based modulation of presynaptic efficacy provides a feedback between neuronal activity and astrocytic transients

Andrey Yu. Verisokin; Pavel O. Lukin; Maxim N. Prudkin; Darya V. Verveyko; Dmitry E. Postnov; Alexey R. Brazhe

doi:10.1117/12.2626012

29 April 2022 Gliotransmitter-based modulation of presynaptic efficacy provides a feedback between neuronal activity and astrocytic transients

Andrey Yu. Verisokin, Pavel O. Lukin, Maxim N. Prudkin, Darya V. Verveyko, Dmitry E. Postnov, Alexey R. Brazhe

Author Affiliations +

Proceedings Volume 12194, Computational Biophysics and Nanobiophotonics; 1219409 (2022) https://doi.org/10.1117/12.2626012
Event: XXV Annual Conference Saratov Fall Meeting 2021; and IX Symposium on Optics and Biophotonics, 2021, Saratov, Russian Federation

Abstract

Astrocytes not only provide for the transfer of nutrients between blood vessels and neurons, but also take part in signaling through nerve tissue and regulate formation, pruning, and plasticity of synapses. Analysis of the impact of the astrocytic domain organization on the local and collective dynamics of neurons is needed for both the fundamental understanding of the mechanisms underlying cognition and for the creation of new methods of neurodegenerative pathology treatment targeted at non-neuronal cells without direct effects on the neural network. Based on the available experimental data, we propose a model study of the role of astrocytic calcium signaling in the regulation of synaptic transmission between neurons in order to elucidate the role played by astrocyte calcium signaling in signaling pathways regulating neural activity. The proposed model is based on the following assumptions: (i) localized release of gliotransmitters depends on the spatiotemporal patterns of calcium activity and is determined by cell morphology and topology of the entire network; (ii) the release of gliotransmitters can lead to spatial segregation of the nervous tissue into regions in which different conditions are maintained, favoring for increased or decreased synaptic efficacy.

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Andrey Yu. Verisokin, Pavel O. Lukin, Maxim N. Prudkin, Darya V. Verveyko, Dmitry E. Postnov, and Alexey R. Brazhe "Gliotransmitter-based modulation of presynaptic efficacy provides a feedback between neuronal activity and astrocytic transients", Proc. SPIE 12194, Computational Biophysics and Nanobiophotonics, 1219409 (29 April 2022); https://doi.org/10.1117/12.2626012

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KEYWORDS

Calcium

Modulation

Neurons

Axons

Neurotransmitter release

Neurotransmitters

3D modeling

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