Quantitative analysis of in vivo skin penetration by confocal Raman spectroscopy

Gerwin J. Puppels; Peter J. Caspers; Tom Bakker Schut; Claudio Nico

doi:10.1117/12.2651539

17 March 2023 Quantitative analysis of in vivo skin penetration by confocal Raman spectroscopy

Gerwin J. Puppels, Peter J. Caspers, Tom Bakker Schut, Claudio Nico

Proceedings Volume 12357, Visualizing and Quantifying Drug Distribution in Tissue VII; 1235704 (2023) https://doi.org/10.1117/12.2651539
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

The presentation will address methodological aspects and limits of detection of confocal Raman spectroscopy for use in quantitative in vivo analysis of skin penetration and permeation of topically applied materials. The differences in penetration rate of skin at different anatomical locations will be illustrated as well as the effect of product formulation on the penetration of an active.

Conference Presentation

Citation Download Citation

Gerwin J. Puppels, Peter J. Caspers, Tom Bakker Schut, and Claudio Nico "Quantitative analysis of in vivo skin penetration by confocal Raman spectroscopy", Proc. SPIE 12357, Visualizing and Quantifying Drug Distribution in Tissue VII, 1235704 (17 March 2023); https://doi.org/10.1117/12.2651539

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