Evaluating cutaneous pharmacokinetics of tazarotene by coherent Raman imaging

Maria Alice Maciel Tabosa; Conor L. Evans; Saara Luna

doi:10.1117/12.2647609

17 March 2023 Evaluating cutaneous pharmacokinetics of tazarotene by coherent Raman imaging

Maria Alice Maciel Tabosa, Conor L. Evans, Saara Luna

Proceedings Volume 12357, Visualizing and Quantifying Drug Distribution in Tissue VII; 123570A (2023) https://doi.org/10.1117/12.2647609
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Identification and validation of approaches for evaluation of the bioavailability of a topically applied drug in the skin represent a work-in-progress. Coherent Raman imaging can quantitatively visualize drug and elucidate pharmacokinetics estimates. Here, we imaged and quantified the uptake of tazarotene through distinct skin layers of perfused in vivo and non-perfused ex vivo nude mouse ear. Differences in the pharmacokinetic values could be seen at all skin depths and, also, between perfused non-perfused skin ears. This technique facilitates the direct observation of drug uptake into the skin layers, shedding light on the mechanisms of drug kinetics into the skin.

Conference Presentation

Citation Download Citation

Maria Alice Maciel Tabosa, Conor L. Evans, and Saara Luna "Evaluating cutaneous pharmacokinetics of tazarotene by coherent Raman imaging", Proc. SPIE 12357, Visualizing and Quantifying Drug Distribution in Tissue VII, 123570A (17 March 2023); https://doi.org/10.1117/12.2647609

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