Measuring skin penetration under in-use conditions

Yousuf Mohammed; Krishna Telaprolu; Jonathan Wei; David Liu; Michael Roberts

doi:10.1117/12.2648108

17 March 2023 Measuring skin penetration under in-use conditions

Yousuf Mohammed, Krishna Telaprolu, Jonathan Wei, David Liu, Michael Roberts

Proceedings Volume 12357, Visualizing and Quantifying Drug Distribution in Tissue VII; 123570C (2023) https://doi.org/10.1117/12.2648108
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Understanding skin drug diffusion under in use conditions is a prerequisite to building accurate and predictive mathematical models. Non-invasive microscopic techniques, combined with use of an epidermal model that retains viability without destroying and disrupting the biological, metabolic, chemical and enzymatic properties of the skin can enable in vitro characterisation of molecular diffusion without the need for in vivo experiments. We studied drug diffusion in the presence and absence of transport inhibitors, to highlight the significance of the right in vitro models, while making key observations of diffusion kinetics and cellular transport.

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Yousuf Mohammed, Krishna Telaprolu, Jonathan Wei, David Liu, and Michael Roberts "Measuring skin penetration under in-use conditions", Proc. SPIE 12357, Visualizing and Quantifying Drug Distribution in Tissue VII, 123570C (17 March 2023); https://doi.org/10.1117/12.2648108

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KEYWORDS

Skin

Diffusion

Mathematical modeling

Molecules

In vivo imaging

Luminescence

MATLAB

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