Quantitative OCT angiography toward 4D blood flow analysis in embryonic cardiovascular system

Michaela A. McCown; Irina V. Larina

doi:10.1117/12.2656704

7 March 2023 Quantitative OCT angiography toward 4D blood flow analysis in embryonic cardiovascular system

Michaela A. McCown, Irina V. Larina

Proceedings Volume 12378, Dynamics and Fluctuations in Biomedical Photonics XX; 1237809 (2023) https://doi.org/10.1117/12.2656704
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Alterations in cardiac development lead to embryonic lethality or congenital heart defects, which affect about 1% of all newborns worldwide. The heart is critical for blood circulation to transport oxygen, nutrients, and waste, but proper blood flow is also key to cardiac development. Early heart contractility and blood flow are suggested by multiple studies to be biomechanical factors that regulate cardiovascular development. Therefore, the ability to reconstruct the dynamic patterns of blood flow in the developing embryos is important to understanding the biomechanical regulation of heart development and improved management of congenital heart defects. Toward this goal, optical coherence tomography (OCT) imaging of mouse embryonic cardiodynamics and novel OCT-based functional analysis methods are actively being developed. Here, we present the development of quantitative OCT angiography toward direction-independent, spatially and temporally resolved blood flow analysis in embryonic vascular structures, which could potentially be expanded to the heart. In contrast to adult blood, individual blood cells can be visualized within the embryonic cardiovascular system. Our approach takes advantage of this feature as well as the periodicity of the cardiac cycle. We demonstrate a capability for spatially resolved flow dynamics in embryonic vasculature in relation to the heartbeat phase. Potentially, the presented method can be expanded to 4D (3D + time) quantitative OCT angiography in the beating heart to enable biomechanical studies.

Conference Presentation

Citation Download Citation

Michaela A. McCown and Irina V. Larina "Quantitative OCT angiography toward 4D blood flow analysis in embryonic cardiovascular system", Proc. SPIE 12378, Dynamics and Fluctuations in Biomedical Photonics XX, 1237809 (7 March 2023); https://doi.org/10.1117/12.2656704

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