A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping

Jake A. J. Bewick; Peter R. T. Munro; Simon R. Arridge; James A. Guggenheim

doi:10.1117/12.2656075

9 March 2023 A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping

Jake A. J. Bewick, Peter R. T. Munro, Simon R. Arridge, James A. Guggenheim

Author Affiliations +

Proceedings Volume 12379, Photons Plus Ultrasound: Imaging and Sensing 2023; 123790D (2023) https://doi.org/10.1117/12.2656075
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Photoacoustic (PA) wavefront shaping (WFS; PAWS) could allow focusing light deep in living tissue, increasing the penetration depth of biomedical optics techniques. PAWS experiments have demonstrated focusing light through rigid scattering media. However, focusing deep in tissue is significantly more challenging. To examine the scale of this challenge, a computational model of the propagation of coherent light in tissue was developed to simulate the focusing of light via PAWS. To demonstrate the model, it was used to simulate focusing in an 800 µm thick tissue-like medium. To show the utility of the model, the focusing was repeated in different conditions illustrative of simplified PAWS experiments involving different spatial resolutions. As expected, a finer spatial resolution led to a brighter focus. By providing a simulation platform for studying PAWS, this work could pave the way to developing systems that can focus light in tissue.

Conference Presentation

Citation Download Citation

Jake A. J. Bewick, Peter R. T. Munro, Simon R. Arridge, and James A. Guggenheim "A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping", Proc. SPIE 12379, Photons Plus Ultrasound: Imaging and Sensing 2023, 123790D (9 March 2023); https://doi.org/10.1117/12.2656075

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