Fe3O4@Au core satellite magnetic nanoparticles to enhance colorimetric immunosensor response

Maria De Luca; Daniele Marra; Adriano Acunzo; Vincenzo Iannotti; Bartolomeo Della Ventura; Raffaele Velotta

doi:10.1117/12.2680212

31 May 2023 Fe₃O₄@Au core satellite magnetic nanoparticles to enhance colorimetric immunosensor response

Maria De Luca, Daniele Marra, Adriano Acunzo, Vincenzo Iannotti, Bartolomeo Della Ventura, Raffaele Velotta

Proceedings Volume 12572, Optical Sensors 2023; 125720O (2023) https://doi.org/10.1117/12.2680212
Event: SPIE Optics + Optoelectronics, 2023, Prague, Czech Republic

Abstract

A newly developed colorimetric immunosensor based on gold-coated magnetic nanoparticles (Fe3O4@Au) is presented, and its application for the detection of human immunoglobulin G (IgG) in water is demonstrated. By taking advantage of both the localized surface plasmon resonance (LSPR) phenomenon of gold nanoparticles and the magnetic property of the core, the Fe3O4@Au immunosensor provides a fast and effective method for detecting analytes. In a sandwich scheme, Fe₃O₄@Au nanoparticles are used to enhance the response of the nanostructured gold surface made of gold nanoparticles randomly placed onto a glass coverslip. Specifically, the detection of the target analyte (human IgG) occurs when Fe₃O₄@Au nanoparticles bind to the target from the top in the presence of a magnetic field, leading to a change in the absorption spectrum of the nanostructure. Preliminary results have shown that the colorimetric immunosensor can achieve a limit of detection of 1 ng/mL, with a measurement carried out in only 10 minutes. The use of gold-coated magnetic nanoparticles in conjunction with the plasmonic surface offers great potential for the sensitive and specific detection of analytes. This could pave the way for future applications of the immunosensor in rapid testing and mass screening

Conference Presentation

Citation Download Citation

Maria De Luca, Daniele Marra, Adriano Acunzo, Vincenzo Iannotti, Bartolomeo Della Ventura, and Raffaele Velotta "Fe₃O₄@Au core satellite magnetic nanoparticles to enhance colorimetric immunosensor response", Proc. SPIE 12572, Optical Sensors 2023, 125720O (31 May 2023); https://doi.org/10.1117/12.2680212

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available