Low-cost retinal imaging for disease progression monitoring at home

Ryo Kubota; Stefan Troller; Matthias Pfister

doi:10.1117/12.2670574

11 August 2023 Low-cost retinal imaging for disease progression monitoring at home

Ryo Kubota, Stefan Troller, Matthias Pfister

Proceedings Volume 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V; 1263207 (2023) https://doi.org/10.1117/12.2670574
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

The unmet medical need of continuously monitoring retinal disease progression asks for an affordable and easy to use medical device that can be used multiple times per week at the patient’s home. A retinal monitor system has been designed for home use, has been built, and tested in a clinical study. The retinal monitor system consists of a handheld device operated by the patient, a tablet with an application, and cloud software. The retinal monitor system has been optimized for low production cost and ease of use for elderly patients while a minimum required performance has been assured to detect changes of retinal thickness and the presence of fluid. Component costs are optimized by relying on the wavelength-tuning capabilities of a VCSEL light source. The small form factor, the lightweight design and an auto-capture functionality enable patients to operate the retinal monitor on their own. The limited performance of low-cost components is compensated by sophisticated signal processing including a deep neural network. Clinical data has been acquired on 20 healthy and 50 diseased eyes to develop the algorithm and estimate the device performance. The clinical results indicate a 95% sensitivity and 95% specificity to detect a change of ±25 μm. Moreover, presence of fluid has been detected with a true positive rate of 97% and a true negative rate of 92%.

Citation Download Citation

Ryo Kubota, Stefan Troller, and Matthias Pfister "Low-cost retinal imaging for disease progression monitoring at home", Proc. SPIE 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V, 1263207 (11 August 2023); https://doi.org/10.1117/12.2670574

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available