CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 12655 > Article
Presentation
6 October 2023 Deep learning-enabled fluorescent point-of-care sensor for multiplexed quantification of biomarkers from serum
Artem Goncharov, Hyou-Arm Joung, Rajesh Ghosh, Gyeo-Re Han, Zachary S. Ballard, Quinn Maloney, Alexandra Bell, Chew Tin Zar Aung, Omai B. Garner, Dino Di Carlo, Aydogan Ozcan
Author Affiliations +
Proceedings Volume 12655, Emerging Topics in Artificial Intelligence (ETAI) 2023; 126550D (2023) https://doi.org/10.1117/12.2678193
Event: SPIE Nanoscience + Engineering, 2023, San Diego, California, United States
Abstract
We demonstrate a multiplexed fluorescent vertical flow assay (fxVFA) processed by a hand-held reader and a deep learning-based algorithm for quantification of three biomarkers, i.e. myoglobin, creatine kinase-MB (CK-MB) and heart-type fatty acid binding protein (FABP) from human serum samples. fxVFA operation takes <15 min and requires 50 µL of serum sample. fxVFA achieved <0.52 ng/mL limits-of-detection for all three analytes with minimal cross-reactivity between the antigens. Furthermore, quantification performance of fxVFA was tested on 16 serum samples and fxVFA-predicted concentrations had >0.9 coefficients of determination and <15 % coefficients of variation with the respect to a standard ELISA test.
Conference Presentation
(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Artem Goncharov, Hyou-Arm Joung, Rajesh Ghosh, Gyeo-Re Han, Zachary S. Ballard, Quinn Maloney, Alexandra Bell, Chew Tin Zar Aung, Omai B. Garner, Dino Di Carlo, and Aydogan Ozcan "Deep learning-enabled fluorescent point-of-care sensor for multiplexed quantification of biomarkers from serum", Proc. SPIE 12655, Emerging Topics in Artificial Intelligence (ETAI) 2023, 126550D (6 October 2023); https://doi.org/10.1117/12.2678193
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Sensors
Point-of-care devices
Multiplexing
Statistical analysis
Detector arrays
Diagnostics
Nanoparticles
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top