Optical imaging modalities for the detection of head and neck cancer margins

Ethan J. Han; Lauran K. Evans; Yazeed Alhiyari; Christian Wooten; Brandon Mo; Maie A. St. John

doi:10.1117/12.3012640

12 March 2024 Optical imaging modalities for the detection of head and neck cancer margins

Ethan J. Han, Lauran K. Evans, Yazeed Alhiyari, Christian Wooten, Brandon Mo, Maie A. St. John

Proceedings Volume 12818, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2024; 1281807 (2024) https://doi.org/10.1117/12.3012640
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Positive surgical margins in head and neck cancers (HNC) are associated with poor survival. Standard frozen section analysis for intraoperative assessment of margins is limited by processing time and sampling error. Optical imaging technologies may address these limitations. We identified the following techniques in a literature search of optical imaging modalities for the detection of head and neck tumor margins: autofluorescence imaging, dynamic optical contrast imaging, optical coherence tomography, narrow band imaging, hyperspectral imaging, Raman spectroscopy, near-infrared fluorescence imaging, confocal laser endomicroscopy, and high-resolution microendoscopy. Penetration depths range from surface level to 6mm, image acquisition times range from real-time to several minutes, and 3/9 require exogenous contrast agents. Reported sensitivity and specificity range from 71-100% and 43-100%, respectively. Each reviewed modality lends unique strengths such as fast image acquisition times, wide field of view, high native contrast, or seamless integration with existing endoscopes. However, none have yet to replace palpation and frozen section analysis in the operating room.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Ethan J. Han, Lauran K. Evans, Yazeed Alhiyari, Christian Wooten, Brandon Mo, and Maie A. St. John "Optical imaging modalities for the detection of head and neck cancer margins", Proc. SPIE 12818, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2024, 1281807 (12 March 2024); https://doi.org/10.1117/12.3012640

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