A brief introduction to Her2 in breast cancer

Liangjuan Zhou; Yule Zheng

doi:10.1117/12.3012985

8 January 2024 A brief introduction to Her2 in breast cancer

Liangjuan Zhou, Yule Zheng

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129240I (2024) https://doi.org/10.1117/12.3012985
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

Breast cancer, takes a large proportion in tumor-associated female death at present. It mainly causes the death of patients through four aspects: cancer cells shedding, spreading, metastasis, forming implanted tumors or breast cancer recurrence. Related studies have shown that about most primary breast cancer have the amplification of Her2 gene or overexpression of the protein. Her2 is a common receptor in cell membrane as monomers but dimerize on ligand binding. The dinner shows as the active form. The activation involves in cell growth. The overexpression of Her2 cause the continuous activation of Her2 downstream pathways, which further induce tumor proliferation and metastasis. The patients with the amplification of Her2 always relate to poor prognosis. In this paper, we focus on the structure, biological future and cellular cascade of Her2. Also, the relationship between Her2 and breast cancer and related targeted therapeutic agents are briefly discussed, to further provide potential clinical application and improve human health.

Citation Download Citation

Liangjuan Zhou and Yule Zheng "A brief introduction to Her2 in breast cancer", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129240I (8 January 2024); https://doi.org/10.1117/12.3012985

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