Research progress of BUB1 in the development of tumor

Yu Guo; Jianlin Li; Yichi Zhang

doi:10.1117/12.3013173

8 January 2024 Research progress of BUB1 in the development of tumor

Yu Guo, Jianlin Li, Yichi Zhang

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129240U (2024) https://doi.org/10.1117/12.3013173
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

A crucial protein that regulates the spindle checkpoint, BUB1 catalyze phosphorylation on serine/threonine residues of target protein, then transduce the downstream cascade. During the cell cycle, BUB1 participates in the control of SAC to maintain proper chromosomal alignment and ensure correct sister chromatid separation. Chromosome instability and aneuploidy in somatic cells can result from the aberrant expression of BUB1, which can also cause functional abnormalities in SAC. Additionally, BUB1 participates in the incidence and progression of malignant tumors through influencing tumor cell proliferation, invasion, migration, and tumor stem cell activities, according to research conducted in recent years. Here, we focus on the structure and biological function of BUB1. Also, this review describes the role of BUB1 in tumorigenesis which associating with the basic molecular structure and its canonical biological function which display the relationship with SAC. Further, we discuss the potential clinical application of BUB1 for providing a new basis for targeted therapy of tumors.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Yu Guo, Jianlin Li, and Yichi Zhang "Research progress of BUB1 in the development of tumor", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129240U (8 January 2024); https://doi.org/10.1117/12.3013173

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