Network pharmacology-based investigation of the molecular mechanisms underlying Sausselia Tianshanensis' potential antiesophageal squamous cell carcinoma activity

Song Jiayu; Xing Jingyin

doi:10.1117/12.3021729

8 January 2024 Network pharmacology-based investigation of the molecular mechanisms underlying Sausselia Tianshanensis' potential antiesophageal squamous cell carcinoma activity

Song Jiayu, Xing Jingyin

Author Affiliations +

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 1292415 (2024) https://doi.org/10.1117/12.3021729
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

The material basis of using Saussurea involucrata in the treatment of esophageal squamous cell carcinoma was studied through bioinformatics, network pharmacology, and molecular docking. The ESCC data chip GSE167488 was obtained from the GEO database. The GEO2R tool was used to identify significantly differentially expressed genes in ESCC. TCMSP was employed to screen for active ingredients and targets of Saussurea involucrata. Human genes related to ESCC were retrieved from the NCBI Gene database. The genes were intersected to obtain 28 common genes, corresponding to 7 effective components of Saussurea involucrata. PPI network and component-target network were constructed. GO biological enrichment and KEGG pathway analysis were performed on the targets in the DAVID database to obtain cancerrelated signal transduction, immune regulation, and other disease pathways. The GEPIA database was used to analyze the survival of 20 targets, and 4 significantly different genes with different expressions in ESCC survival rate were screened. Molecular docking was performed and it was found that homoplantaginin, isoimperatorin, kaempferol, luteolin, rosarylline, and quercetin had a good combination with target MMP1, PTGS2, SERPINE1, and VCAM1.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Song Jiayu and Xing Jingyin "Network pharmacology-based investigation of the molecular mechanisms underlying Sausselia Tianshanensis' potential antiesophageal squamous cell carcinoma activity", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 1292415 (8 January 2024); https://doi.org/10.1117/12.3021729

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