mRNA vaccines: a powerful tool in cancer treatment

Junda Qian

doi:10.1117/12.3012829

8 January 2024 mRNA vaccines: a powerful tool in cancer treatment

Junda Qian

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129241A (2024) https://doi.org/10.1117/12.3012829
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

In recent years, despite the remarkable achievements in tumor research, malignant tumor, as the second leading cause of death in the world, still threatens human health.The main methods of cancer treatment include surgical therapy, chemotherapy, general radiation therapy, stereotactic radiation therapy, immunotherapy, endocrine therapy, guided therapy, cryotherapy and warming therapy, and gene therapy. As a potential treatment method, mRNA tumor vaccines, that use mRNA molecules to deliver instructions to cells in the body to make specific proteins that trigger an immune response, have become a hot research field currently. By optimizing and improving the mRNA preparation strategy and mRNA vaccine delivery system, the key technology of mRNA tumor vaccine research and development has achieved rapid development and has accelerated the research process and clinical application of mRNA therapy, as well as has greatly overcome bottleneck problems such as the poor stability, low rate and delivery of mRNA vaccines in the past.These progresses will make the technology of mrna tumor vaccine more and more mature, and the possibility of cancer cure will be further improved. This review systematically introduces optimization of mRNA preparation strategies, mRNA vaccine delivery systems, specific applications of mRNA tumour vaccines, and discusses challenges and opportunities for future development.

Citation Download Citation

Junda Qian "mRNA vaccines: a powerful tool in cancer treatment", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129241A (8 January 2024); https://doi.org/10.1117/12.3012829

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KEYWORDS

Tumors

Proteins

Cancer

Radiotherapy

Oncology

In vitro testing

Nanoparticles

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