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8 January 2024 Blood group antigens and antibodies in the newborns
Sh. Gabaidze, M. Nagervadze, L. Akhvlediani, N. Nakashidze, A. Alfilo, I. Tsintsadze, N. Gorgadze, R. KhuKhunaishvili, M. Koridze, T. Koiava, K. Dolidze, T. Bakhtadze
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Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129242N (2024) https://doi.org/10.1117/12.3012861
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom
Abstract
Introduction. ABO blood group determined by presence of A and B antigens on the erythrocyte and of anti-A and anti-B antibodies in the serum. Erythrocyte natural antibodies are IgM type, and usually not present in newborns, but appear in the first year of life. Unlike adults, in some newborns, antigens A and B are poorly expressed and the antibodies may be absent in the blood serum. The Rh antigen is expressed in newborns in the same way as in adults. We were interested to find these characteristics in our region’s newborns. Research materials and methods. A total of 208 newborns samples were collected. Both forward and reverse blood typing procedures were performed with monoclonal anti-A, anti-B, anti- A1, and anti-H antibodies and the standard A and B blood group erythrocytes for typing the ABO blood group antigens. Result. In our study we find that in the majority case (43.94±3.5%) of newborns the natural origin anti-A and anti-B antibodies was not detected, in same particular case (14.14±2.4%) of O(I) blood group individuals it was partially synthesis. 41.92±3.5% of our studied newborns were expressed natural antibodies as an adults. Blood donor population the frequency of A2 subgroup is very less; while in newborn it is equal to 85.41±3.5%. Conclusion. Our research shows that in majority cases of newborns ABO antibodies are not expressed and also we found the predominance of the A2 and A2B phenotypes in the newborns. Since the postnatal period of development is required for the full expression of ABO system antigens.
(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
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Sh. Gabaidze, M. Nagervadze, L. Akhvlediani, N. Nakashidze, A. Alfilo, I. Tsintsadze, N. Gorgadze, R. KhuKhunaishvili, M. Koridze, T. Koiava, K. Dolidze, and T. Bakhtadze "Blood group antigens and antibodies in the newborns", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129242N (8 January 2024); https://doi.org/10.1117/12.3012861
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KEYWORDS
Blood
Antibodies
Biological samples
Plasma
Red blood cells
Medicine
Proteins
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