Overcoming toxicity challenges in CAR-T therapy: mechanisms and mitigation strategies

Zixuan Zhuang

doi:10.1117/12.3012917

8 January 2024 Overcoming toxicity challenges in CAR-T therapy: mechanisms and mitigation strategies

Zixuan Zhuang

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129242U (2024) https://doi.org/10.1117/12.3012917
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of B cell lymphomas and myelomas, with multiple products now approved by the US FDA. However, the clinical success of CAR-T therapy is hindered by its toxicity, which remains the most frequent and severe side effect during the treatment process. To address this issue, this essay focuses on the mechanisms of toxicity in this therapy and the emerging strategies under development to overcome toxicity. Through a detailed review of the literature, this essay examines the various types of toxicities that can occur during CAR-T therapy, such as cytokine release syndrome and neurotoxicity, and discusses the underlying mechanisms of each type of toxicity. Furthermore, this essay highlights the current strategies being developed to reduce toxicity, including gene editing, combinatorial approaches, and the use of checkpoint inhibitors, among others. By addressing the current challenges and potential solutions to toxicity in CAR-T therapy, this essay provides insight into the future development of this exciting therapeutic approach.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Zixuan Zhuang "Overcoming toxicity challenges in CAR-T therapy: mechanisms and mitigation strategies", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129242U (8 January 2024); https://doi.org/10.1117/12.3012917

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