Exploration of the association between serum uric acid and urine albumin-to-creatinine ratio in adults: NHANES 2011–2020.03

Shuyuan Zhang

doi:10.1117/12.3013200

8 January 2024 Exploration of the association between serum uric acid and urine albumin-to-creatinine ratio in adults: NHANES 2011–2020.03

Shuyuan Zhang

Author Affiliations +

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129243X (2024) https://doi.org/10.1117/12.3013200
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

Substantial studies have consistently demonstrated a compelling correlation between either serum uric acid (SUA) or urine albumin-to-creatinine ratio (uACR) and renal diseases, underscoring the significant linkages between these biomarkers and renal health. However, the relationship between uACR and SUA remain unknown with little evidence examining the relationship in general US population. The objective of this investigation is to assess the correlation between SUA and uACR in adults in the United States. The NHANES 2011–2020.3 dataset was used, with total 24,054 participants eligible after the data selection. Clinical characteristics were compared between SUA and uACR groups. To investigate the association between SUA and uACR, both univariate and multivariate linear regression analysis were utilized. After adequately adjusting confounding factors, a strong association was revealed between SUA and uACR for adults in the US. The findings from the multivariate linear regression analysis revealed notable associations between various factors and uACR levels. Specifically, increasing age, serum creatinine level, and serum glucose level exhibited significant positive correlations with elevated uACR levels. Conversely, serum albumin and SUA demonstrated significant negative correlations with uACR levels. However, the association was not significant in males with chronic kidney disease (CKD), those aged 65 and older, or those who were obese. There appears to be a significant correlation between SUA levels and uACR levels within the general population of the United States, indicating a noteworthy association between two variables, however the relationship between SUA and uACR might need to be further analyzed using other biochemical data such as ROS and IL-1β level.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Shuyuan Zhang "Exploration of the association between serum uric acid and urine albumin-to-creatinine ratio in adults: NHANES 2011–2020.03", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129243X (8 January 2024); https://doi.org/10.1117/12.3013200

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KEYWORDS

Linear regression

Kidney

Glucose

Statistical analysis

Blood

Diseases and disorders

Cardiovascular disorders

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