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Energy sensitive and photon counting detectors can provide improved tissue visualization and material quantification capabilities in Cone Beam Computed Tomography (CBCT) systems. However, their implementation in CBCT systems is more challenging, which is in part due to high fluence of scattered X-rays in wide cone angle CBCT geometry. Specifically, high scatter contamination in lower energy spectrum challenges reconstruction of high fidelity CBCT images by using lower energy X-rays. To address this problem, we investigated a robust scatter rejection with 2D antiscatter grids in a benchtop photon counting and compact CBCT system. The benchtop system employs a 35 cm wide CdTe photon counting detector with two energy thresholds. To reject scatter, a dedicated 2D antiscatter grid (2D grid) prototype made from tungsten was developed and mounted directly on the detector. To correct residual scatter not stopped by the 2D grid, a measurement-based scatter correction method, referred to as Grid-based Scatter Sampling (GSS), was utilized. Without 2D grid, scatter to primary ratio (SPR) reached 2.3 in the 15-40 keV energy bin. SPR was factor of 3 higher in the lowest energy bin when compared to the highest energy bin (90-120 keV). With the 2D grid, SPR was reduced below 0.14, and SPR values were more homogenous across the energy spectrum. CT number nonuniformity was factor of 3 lower in both low and high energy bin CBCT reconstructions. Improvement in contrast to noise ratio and contrast was more pronounced in the low energy bin CBCT images. This work indicates that 2D grids can significantly reduce spectral contamination caused by scatter in photon counting compact CBCT, and potentially enable higher fidelity CBCT image reconstructions.
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