Optofluidic integrated one-dimensional photonic crystal biosensor for tumor marker detection

Qing Shi; Shilun Feng; Jianlong Zhao

doi:10.1117/12.3003776

18 December 2023 Optofluidic integrated one-dimensional photonic crystal biosensor for tumor marker detection

Qing Shi, Shilun Feng, Jianlong Zhao

Proceedings Volume 12963, AOPC 2023: Optical Sensing, Imaging, and Display Technology and Applications; and Biomedical Optics; 129631U (2023) https://doi.org/10.1117/12.3003776
Event: Applied Optics and Photonics China 2023 (AOPC2023), 2023, Beijing, China

Abstract

We propose a silicon based optofluidic one-dimensional photonic crystal biosensor structure for tumor marker detection, which is composed of a nanobeam resonator transducer with excellent detection limit performance, a filter with low sidelobe jitter and a microfluidics roof. Using the three-dimensional finite difference time domain method, a one-dimensional photonic crystal slot nanobeam resonator transducer optimization model consisting of a circular hole array linearly decreasing from the center to both ends was obtained. Under the influence of absorption loss of biological solution, the transducer works in the communication E-band, with the Q value still up to 10538, refractive index sensitivity of 338 nm/RIU, and refractive index detection limit of 10^-5 RIU, corresponding to the detection of fg/mL carcinoembryonic antigen, which can be directly used for the detection of tumor marker under the capture of antibody probes in microfluidics chip. By optimizing the apertures on both sides of one-dimensional photonic crystals with a taper shape, a cutoff filter with low sidelobe jitter can effectively filter out the high-order resonant peaks of the transducer, forming a large free wavelength detection range. The microfluidics channel is used to inject different refractive index liquids, and the cut-off wavelength can match the detection requirements of different concentrations of tumor markers. The sensor structure is expected to build a multi-channel parallel lab-on-chip through splitters and detect multiple tumor markers simultaneously.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Qing Shi, Shilun Feng, and Jianlong Zhao "Optofluidic integrated one-dimensional photonic crystal biosensor for tumor marker detection", Proc. SPIE 12963, AOPC 2023: Optical Sensing, Imaging, and Display Technology and Applications; and Biomedical Optics, 129631U (18 December 2023); https://doi.org/10.1117/12.3003776

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KEYWORDS

Biosensors

Cancer detection

Transducers

Mathematical optimization

Optical filters

Photonic crystals

Tumors

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