Application of 99mTc-labeled hematoporphyrin-derivative in the radio imaging diagnosis of bladder tumors

Yuanfang Zhang; Nianli Shuang; Tingjie Miao; Li Zhang

doi:10.1117/12.136992

5 March 1993 Application of 99mTc-labeled hematoporphyrin-derivative in the radio imaging diagnosis of bladder tumors

Yuanfang Zhang, Nianli Shuang, Tingjie Miao, Li Zhang

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.136992
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

It has been proven that the hematoporphyrin derivatives (HPD) could be accumulated and retained in malignant tissues for a long time. Using a newly established procedure, we labelled HPD with radioactive isotope 99mTc. These studies suggest that: 99mTc-HPD can be used to study the in vivo distribution and metabolism of the HPD; that the accumulation and retention of 99mTc-HPD in tumor tissues is not highly specific; that the 99mTc-HPD radio-imaging can be used to study the distribution and metabolism of HPD in the human body; and that, if the radioactive ratio of tumor to surrounding tissues is high enough, it can be used to localize the tumor qualitatively. In this article the desirable time for imaging, the diagnostic criteria, and the correlation between the sensitivity and the pathologic grade, stage, and size of the bladder tumor are discussed.

Citation Download Citation

Yuanfang Zhang, Nianli Shuang, Tingjie Miao, and Li Zhang "Application of 99mTc-labeled hematoporphyrin-derivative in the radio imaging diagnosis of bladder tumors", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.136992

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