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5 March 1993 Immunophotosensitizer: the preparation and antitumor properties of monoclonal antibody-hematoporphyrin conjugate
Shan Bai, Cheng-gui Liu, Zhong-He Guo M.D.
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Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.137022
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China
Abstract
The immunophotosensitizer was prepared by conjugating hematoporphyrin (HP) with anti-CEA and anti-colonic cancer monoclonal antibody (McAb), respectively. In vitro, the anti-CEA McAb-HP conjugate showed cytotoxicity for human colonic cancer cell line SW1116 which was CEA positive, but no cytotoxicity for the CEA-negative Hep-2 cell line. The cytotoxicity of immunophotosensitizer was much higher than the McAb alone, the HP alone, or the mixture of McAb and HP. In vivo experiments, the nude mice bearing the xenografted human colonic cancer were used to test the activity of the anti-colonic cancer McAb-HP conjugate. The results demonstrated that the tumor necrotic areas of the conjugate-treated animals were notably larger than those of the free HP-treated animals. The specificity offered by the McAb permits increase of the aggregation of the drug at the tumor site. This property makes it possible to use a lower effective dosage of the drug, which minimizes undesired side effects. Further experiments are now in progress.
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Shan Bai, Cheng-gui Liu, and Zhong-He Guo M.D. "Immunophotosensitizer: the preparation and antitumor properties of monoclonal antibody-hematoporphyrin conjugate", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.137022
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KEYWORDS
Tumors
Cancer
In vitro testing
Blood
In vivo imaging
Proteins
Image analysis
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