Free-electron laser irradiation of the cornea

Denis M. O'Day M.D.; Richard F. Haglund Jr.; Regan Logan M.D.; Michael Borne

doi:10.1117/12.148040

14 July 1993 Free-electron laser irradiation of the cornea

Denis M. O'Day M.D., Richard F. Haglund Jr., Regan Logan M.D., Michael Borne

Proceedings Volume 1854, Free-Electron Laser Spectroscopy in Biology, Medicine, and Materials Science; (1993) https://doi.org/10.1117/12.148040
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

The Free Electron laser was used to explore ablative and toxic effects of infrared irradiation of the cornea at wavelengths ranging from 2.5 - 4.0 micrometers including the peak absorptive wavelength for water of 2.94 micrometers . The macropulse length was 6 microsecond(s) . Effects were studied by visible light and scanning electron microscopies. Ablation was noted at a threshold fluence of 550 - 750 mJ(DOT)cm^-2 and above at a wavelength of 2.94 micrometers . Ablation was accompanied by a distinct zone of tissue denaturation extending up to 12 micrometers into the adjacent tissue. Thermal denaturation appears to be a significant effect of infrared free-electron irradiation on the cornea and appears to be a consequence of the relatively long macropulse duration.

Citation Download Citation

Denis M. O'Day M.D., Richard F. Haglund Jr., Regan Logan M.D., and Michael Borne "Free-electron laser irradiation of the cornea", Proc. SPIE 1854, Free-Electron Laser Spectroscopy in Biology, Medicine, and Materials Science, (14 July 1993); https://doi.org/10.1117/12.148040

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available