Assessment of coronary vasomotion by intracoronary ultrasound

Patrick J. Dupouy; Jean Luc Dubois-Rande; Gabriel Pelle; Dominique Gallot; Herbert J. Geschwind M.D.

doi:10.1117/12.146570

23 June 1993 Assessment of coronary vasomotion by intracoronary ultrasound

Patrick J. Dupouy, Jean Luc Dubois-Rande, Gabriel Pelle, Dominique Gallot, Herbert J. Geschwind M.D.

Proceedings Volume 1878, Diagnostic and Therapeutic Cardiovascular Interventions III; (1993) https://doi.org/10.1117/12.146570
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Recently, new intravascular ultrasound devices for intracoronary use became available. The aim of the study was to evaluate the accuracy of intravascular ultrasound for the assessment of coronary artery vasomotion and endothelial function in patients with atherosclerosis. Twenty patients with luminal irregularities on coronary angiogram and a high cholesterol level (287 +/- 19 mg/dl) (group 1) and 6 patients with angiographically smooth arteries and a minimally elevated cholesterol level (197 +/- 12 mg/dl) (group 2) were studied. A mechanical intravascular ultrasound probe (4.3 French, 30 MHz, Cardiovascular Imaging Systems) was placed into the proximal segment of the coronary artery. Off-line measurements of the lumen area and calculation of mean intimal thickness indice was performed using digitized ultrasound images. Endothelial function was studied during a sympathetic stimulation by a cold pressor test and after intracoronary administration of papaverine and linsidomine. Mean intimal thickness was higher in group 1 than in group 2 (1.52 +/- 0.64 mm vs. 0.18 +/- 0.08 mm, p < 0.001). Linsidomine infusion induced a significant vasodilating effect in both groups (p < 0.001).

Citation Download Citation

Patrick J. Dupouy, Jean Luc Dubois-Rande, Gabriel Pelle, Dominique Gallot, and Herbert J. Geschwind M.D. "Assessment of coronary vasomotion by intracoronary ultrasound", Proc. SPIE 1878, Diagnostic and Therapeutic Cardiovascular Interventions III, (23 June 1993); https://doi.org/10.1117/12.146570

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KEYWORDS

Arteries

Ultrasonography

Angiography

Intravascular ultrasound

Image segmentation

Imaging systems

Cardiovascular magnetic resonance imaging

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