Immunophototherapy for the treatment of cancer of the larynx

Kenneth J. Schlager; Manuel P. Clemente

doi:10.1117/12.146305

18 June 1993 Immunophototherapy for the treatment of cancer of the larynx

Kenneth J. Schlager, Manuel P. Clemente

Proceedings Volume 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II; (1993) https://doi.org/10.1117/12.146305
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Immunophototherapy (IPT) is an experimental method of medical diagnosis and treatment the seeks to provide for the initial detection and subsequent selective destruction of diseased cancer cells such as the squamous carcinoma cells found in malignant tumors resident in cancer of the larynx. Monoclonal antibodies that are specific to squamous cells will be used to detect and treat this neck cancer. These antibodies are tagged with photosensitive compounds and metal colloids and then intravenously injected into the patient. The tagged antibodies quickly and selectively bind to the squamous cells in the larynx and other affected organs. The cancer cells are then selectively destroyed by irradiation of these complexes with light of the proper wavelength. This light activates the photosensitive material which then creates singlet oxygen that destroys the cells. Toxic products of lysis are quickly discharged from the body by activation of the reticuloendothelial system. IPT has been demonstrated to be very effective in the in vitro selective destruction of specified cell types.

Citation Download Citation

Kenneth J. Schlager and Manuel P. Clemente "Immunophototherapy for the treatment of cancer of the larynx", Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); https://doi.org/10.1117/12.146305

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