Photodynamic therapy: development of a treatment and dosimetry system adapted to superficial tumors of the bladder

Dominique Lignon; Y. Jaboin; D. Wolf; Anne Meunier-Reynes; Francois H. Guillemin

doi:10.1117/12.146315

18 June 1993 Photodynamic therapy: development of a treatment and dosimetry system adapted to superficial tumors of the bladder

Dominique Lignon, Y. Jaboin, D. Wolf, Anne Meunier-Reynes, Francois H. Guillemin

Author Affiliations +

Proceedings Volume 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II; (1993) https://doi.org/10.1117/12.146315
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Superficial tumors of the bladder or in situ carcinoma could be interesting indications of Photodynamic Therapy (PDT), since a total mutilating cystectomy could be avoided. The plurifocality of the lesions requires a treatment of the whole mucose; the quantity of light energy must be homogenous and sufficient to induce a therapeutic effect, still non toxic for normal tissues. We therefore developed a system of treatment and intravesical dosimetry control so that the operator can have precise information on the light repartition in the bladder in real time to enable him to optimize the positioning of the irradiation source. This intravesical device consists of twelve light sensors with optical fiber distributed symmetrically against the walls of the bladder; the emitting source is constituted of a scattering isotropic sphere. The signals emitted by the sensors are converted into tension. The acquisition part of the system values consists of two parts : an analogic part, the values are multiplexed on a same oscilloscope track to see in real time their evolution according to the position of the emitting source. The other part is constituted by the numeric acquisition of values for further analysis. We developed, from a mathematical modelisation of the bladder, a centering program of the diffusor that indicates its position in the bladder, as well as a cartography program where the bladder is re-built by interpolation with the different lighting levels.

Citation Download Citation

Dominique Lignon, Y. Jaboin, D. Wolf, Anne Meunier-Reynes, and Francois H. Guillemin "Photodynamic therapy: development of a treatment and dosimetry system adapted to superficial tumors of the bladder", Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); https://doi.org/10.1117/12.146315

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KEYWORDS

Bladder

Photodynamic therapy

Light sources and illumination

Optical spheres

Tumor growth modeling

Sensors

Tumors

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