Transcutaneous bilirubinometry during phototherapy

Laura Ronchi; Giovanni Agati; Franco Fusi; Riccardo Pratesi

doi:10.1117/12.167307

1 February 1994 Transcutaneous bilirubinometry during phototherapy

Laura Ronchi, Giovanni Agati, Franco Fusi, Riccardo Pratesi

Proceedings Volume 2084, Biomedical Optoelectronic Devices and Systems; (1994) https://doi.org/10.1117/12.167307
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Transcutaneous bilirubinometry based on reflectance spectroscopy technique requires the modelling of bilirubin photochemistry and metabolism in skin, and the solution of inverse problems to derive pigment concentrations from spectral measurements. The influence of bilirubin photochemistry occurring during the initial stage of phototherapy on the reflectance spectrum of an icteric tissue is analyzed using a 5-layer skin model, and an algorithm is presented to evaluate bilirubin concentration during phototherapy. An in vivo reflectance spectrum during phototherapy is presented where the configurational, reversible photoisomerization of bilirubin is observed for the first time.

Citation Download Citation

Laura Ronchi, Giovanni Agati, Franco Fusi, and Riccardo Pratesi "Transcutaneous bilirubinometry during phototherapy", Proc. SPIE 2084, Biomedical Optoelectronic Devices and Systems, (1 February 1994); https://doi.org/10.1117/12.167307

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