Noninvasive optical imaging of localized absorption and scattering changes during functional activation of the human brain: an evaluation and feasibility study

Christina Hirth; Shuoming Zhou; Chunhua Xie; Shoko Nioka; Britton Chance

doi:10.1117/12.280230

18 August 1997 Noninvasive optical imaging of localized absorption and scattering changes during functional activation of the human brain: an evaluation and feasibility study

Christina Hirth, Shuoming Zhou, Chunhua Xie, Shoko Nioka, Britton Chance

Author Affiliations +

Proceedings Volume 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II; (1997) https://doi.org/10.1117/12.280230
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

In the present study we evaluated a new 50 MHz single wavelength multi-source detector imaging system for noninvasive optical imaging of human brain function. The system is based on phase resolved technology and allows measurements in remission mode of changes in phase shift and light intensity in the phased array approach and the conventional phase modulation approach. To evaluate the potentials and limitations of the system with respect to functional brain imaging we assessed the sensitivity of imaging based on photon migration pattern and absorption changes in the two different approaches as a function of object depth in a homogeneous brian model under controlled conditions. Furthermore first results using this technique for noninvasive optical imaging of functional brain activation in human subjects are presented and discussed with respect to potentials and limitations of the respective parameter.

Citation Download Citation

Christina Hirth, Shuoming Zhou, Chunhua Xie, Shoko Nioka, and Britton Chance "Noninvasive optical imaging of localized absorption and scattering changes during functional activation of the human brain: an evaluation and feasibility study", Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); https://doi.org/10.1117/12.280230

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
11 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Brain

Phase modulation

Phase shifts

Phased arrays

Neuroimaging

Optical imaging

Absorption

Show All Keywords

Keywords/Phrases

Search In:

Publication Years