Adaptation of spectroscopic tools from high-throughput screening of combinatorial chemistry libraries to process chemical analysis

Radislav A. Potyrailo

doi:10.1117/12.456106

14 February 2002 Adaptation of spectroscopic tools from high-throughput screening of combinatorial chemistry libraries to process chemical analysis

Radislav A. Potyrailo

Author Affiliations +

Proceedings Volume 4578, Fiber Optic Sensor Technology and Applications 2001; (2002) https://doi.org/10.1117/12.456106
Event: Environmental and Industrial Sensing, 2001, Boston, MA, United States

Abstract

This paper summarizes our recent activities to develop analytical spectroscopic tools for high-throughput screening (HTS) of combinatorial chemistry libraries and the adaptation of the developed techniques to more traditional, i.e., laboratory and manufacturing, scales. It is shown that, for a broad variety of applications, optical spectroscopic detection methods have a suite of attractive features that make them almost ideal HTS tools. Strategies for the development of new high-throughput screening tools are presented, followed by analysis of requirements for development of multivariate data analysis methods for prediction of properties of combinatorial materials, determination of contributing factors to combinatorial-scale chemical reactions using evolving factor analysis and multivariate curve resolution chemometric methods, high- throughput optimization of process parameters, and applicability of the developed HTS tools for in-line monitoring of scaled-up reactions.

Citation Download Citation

Radislav A. Potyrailo "Adaptation of spectroscopic tools from high-throughput screening of combinatorial chemistry libraries to process chemical analysis", Proc. SPIE 4578, Fiber Optic Sensor Technology and Applications 2001, (14 February 2002); https://doi.org/10.1117/12.456106

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available