Novel silicon microchannels device for use in red blood cell deformability studies

Xiao-Lin Zheng; Yan-Jian Liao; Wen-Xian Zhang

doi:10.1117/12.445716

16 October 2001 Novel silicon microchannels device for use in red blood cell deformability studies

Xiao-Lin Zheng, Yan-Jian Liao, Wen-Xian Zhang

Proceedings Volume 4602, Semiconductor Optoelectronic Device Manufacturing and Applications; (2001) https://doi.org/10.1117/12.445716
Event: International Symposium on Optoelectonics and Microelectronics, 2001, Nanjing, China

Abstract

Currently, a number of techniques are used to access cell deformability. We study a novel silicon microchannels device for use in red blood cell deformability. The channels are produced in silicon substrate using microengineering technology. The microgrooves formed in the surface of a single-crystal silicon substrate. They were converted to channels by tightly covering them with an optical flat glass plate. An array of flow channels (number 950 in parallel) have typical dimensions of 5 micrometers width X 5.5 Xm depth, and 30 micrometers length. There the RBC's are forced to pass through channels. Thus, the microchannels are used to simulate human blood capillaries. It provides a specific measurement of individual cell in terms of both flow velocity profile and an index of cell volume while the cell flow through the channels. It dominates the complex cellular flow behavior, such as, the viscosity of whole blood is a nonlinear function of shear rate, index of filtration, etc.

Citation Download Citation

Xiao-Lin Zheng, Yan-Jian Liao, and Wen-Xian Zhang "Novel silicon microchannels device for use in red blood cell deformability studies", Proc. SPIE 4602, Semiconductor Optoelectronic Device Manufacturing and Applications, (16 October 2001); https://doi.org/10.1117/12.445716

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