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5 June 2007 Stochastic trigger for clathrin-coated vesicle biogenesis
Ralph Nossal
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Proceedings Volume 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems; 66020J (2007) https://doi.org/10.1117/12.729597
Event: SPIE Fourth International Symposium on Fluctuations and Noise, 2007, Florence, Italy
Abstract
Kinetic aspects of receptor-mediated endocytosis are identified, particularly as relating to the stochastic formation and released of clathrin coated vesicles at the plasma membrane. We discuss how one might account for the coordinated steps of this process, including receptor activation, association with adaptor proteins, coat formation, and the role of phosphoinosotide metabolism as a regulatory mechanism. In anticipation of building a detailed mathematical theory, we discuss an earlier treatment of the way threshold fluctuations affect the firing probability of nerve axons (H. Lecar, and R. Nossal, Biophys. J. 11, pp. 1048--1067, 1971), in which equations were analyzed by distinguishing different time-scales to identify pertinent kinetic variables
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Ralph Nossal "Stochastic trigger for clathrin-coated vesicle biogenesis", Proc. SPIE 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, 66020J (5 June 2007); https://doi.org/10.1117/12.729597
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KEYWORDS
Proteins
Plasma
Receptors
Stochastic processes
Thin film coatings
Axons
Mode conditioning cables
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