Diffractometry analysis of human and rat erythrocytes deformability under ischemia

Andrei E. Lugovtsov; Alexander V. Priezzhev; Sergei Yu. Nikitin; Vladimir B. Koshelev

doi:10.1117/12.728507

13 July 2007 Diffractomery analysis of human and rat erythrocytes deformability under ischemia

Andrei E. Lugovtsov, Alexander V. Priezzhev, Sergei Yu. Nikitin, Vladimir B. Koshelev

Proceedings Volume 6633, Biophotonics 2007: Optics in Life Science; 66332G (2007) https://doi.org/10.1117/12.728507
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

In this work, the analysis of human and rat red blood cells (RBC) deformability, internal viscosity and yield stress of RBC in norm and ischemia was performed by means of laser diffractometry - a modern technique allowing for measuring the flexibility of RBC, which determines the blood flow parameters in vessels. Ischemic diseases of people and animals are accompanied with deterioration of microrheologic properties of their blood, in particular, with impairing the RBC deformability. Human RBCs were obtained from the blood of healthy individuals and from patients suffering from ischemic diseases. The RBC deformability indices from both groups of individuals were measured. Rat RBCs were obtained from a control group of animals and from a group with experimentally induced ischemia (EII). This animal model is frequently used for studying the response of an organism to ischemia. The effect of semax, a medication that is frequently used for therapeutic treatments of human brain diseases in clinical practice, on RBC deformability was studied with its application in vitro and in vivo. It is shown that in human ischemic patients, the deformability index of RBC was lower than that from healthy individuals. Both in vivo and in vitro applied semax positively influences the impaired deformability properties of RBCs of ischemic rats.

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Andrei E. Lugovtsov, Alexander V. Priezzhev, Sergei Yu. Nikitin, and Vladimir B. Koshelev "Diffractomery analysis of human and rat erythrocytes deformability under ischemia", Proc. SPIE 6633, Biophotonics 2007: Optics in Life Science, 66332G (13 July 2007); https://doi.org/10.1117/12.728507

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KEYWORDS

Blood

Ischemia

Diffraction

In vitro testing

In vivo imaging

Brain

Laser scattering

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