Role of collagen in terahertz absorption in skin

Priyamvada Tewari; Martin O. Culjat; Zachary D. Taylor; Jonathan Y. Suen; Benjamin O Burt; Hua Lee; Elliott R. Brown; Warren S. Grundfest M.D.; Rahul S. Singh

doi:10.1117/12.816433

24 February 2009 Role of collagen in terahertz absorption in skin

Priyamvada Tewari, Martin O. Culjat, Zachary D. Taylor, Jonathan Y. Suen, Benjamin O Burt, Hua Lee, Elliott R. Brown, Warren S. Grundfest M.D., Rahul S. Singh

Author Affiliations +

Proceedings Volume 7169, Advanced Biomedical and Clinical Diagnostic Systems VII; 71691A (2009) https://doi.org/10.1117/12.816433
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Reflective terahertz (THz) imaging may potentially become a valuable tool in determining skin hydration due to its non-ionizing photon energy, high sensitivity to water concentration and ability to penetrate through clothing. The high absorption coefficient of water in the THz range is responsible for contrast between substances with lesser or higher degrees of water saturation. Water content, as well as collagen fiber arrangement, varies between different layers of skin. This study sought to determine whether the high THz absorption in water could be exploited to distinguish between these layers. Porcine skin specimens were sectioned into samples of increasing thickness, with the undersides corresponding to different layers in skin. The undersides of the samples were scanned using a THz imaging system operating at a center frequency of 0.5 THz with 0.125 THz of noise-equivalent bandwidth at a standoff of 4 cm and a spot size of 13 mm. Collagen solutions of varying hydrations were also prepared and raster scanned with the same system. The reflectivity of the deeper layers of skin was found to be higher than that of the upper layers, indicating that the deeper layers are more hydrated. The collagen solutions with higher hydration also had higher THz reflectivity. These results suggested that THz is able to distinguish between different layers of skin based on water content and the nature of its association with components in skin.

Citation Download Citation

Priyamvada Tewari, Martin O. Culjat, Zachary D. Taylor, Jonathan Y. Suen, Benjamin O Burt, Hua Lee, Elliott R. Brown, Warren S. Grundfest M.D., and Rahul S. Singh "Role of collagen in terahertz absorption in skin", Proc. SPIE 7169, Advanced Biomedical and Clinical Diagnostic Systems VII, 71691A (24 February 2009); https://doi.org/10.1117/12.816433

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